寻常性银屑病皮损表皮中TGF-β受体活化Smad蛋白表达的检测  

Decreased expression of TGF-β receptor-activated Smads in epidermis of psoriatic lesion

作　　者：叶超然[1] 何威[1] 吴军[1] 黎智[1] 杨进清[1] 黄海[1] 何云志[1] 王儒鹏[1] 

机构地区：[1]第三军医大学新桥医院皮肤科,重庆400037

出　　处：《临床皮肤科杂志》2008年第1期17-19,共3页Journal of Clinical Dermatology

基　　金：第三军医大学回国人员科研基金资助项目(XG200356)

摘　　要：目的:探讨转化生长因子(transforming growth factor,TGF)-β受体活化Smad——[Smad1、Smad2、Smad3(Smad1/2/3)]和磷酸化Smad2/3(p-Smad2/3)蛋白在寻常性银屑病皮损中的表达及其意义。方法:采用EliVision法免疫组化技术分别检测寻常性银屑病皮损与正常对照皮肤中Smad1/2/3和p-Smad2/3蛋白的表达情况。结果:与正常对照皮肤相比,Smad1/2/3和p-Smad2/3蛋白在寻常性银屑病皮损表皮中的表达显著降低。结论:寻常性银屑病皮损表皮中Smad1/2/3和p-Smad2/3蛋白表达降低,可通过阻断TGF-β信号转导,有助于寻常性银屑病皮损角质形成细胞过度增殖状态的发生和发展。Objective： To investigate the expression and significance of Smadl, Smad2, Smad3 and phosphorylated-Smad2/3 （p-Smad2/3） in psoriatic lesions. Methods： EliVision immunohistochemical technique was used to detect the distribution and expression of Smadl/2/3 and p-Smad2/3 in psoriatic lesions and skin specimens 6f normal controls. Results： The expression of Smadl/2/3 and p-Smad2/3 was significantly down-regulated in psoriatic epidermis in comparison with that of normal control skins. Conclusions： Reduced expression of Smadl/2/3 and p-Smad2/3 proteins in psoriatic epidermis might contribute to the formation of hyperplastic epidermis in psoriatic lesions via blocking of TGF-β signal transduetion.

关 键 词：银屑病 转化生长因子-Β Smad1/2/3 P-SMAD2/3 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]