Diethylamine/nitricoxide与硝普钠控制性降压效果的比较  

Comparision of the hypotension induced by diethylamine/nitric oxide and nitroprusside

作　　者：王俊科[1] 崔涌[1] 盛卓人[1] 张倩[1] 宋冰冰[1] 孙新艳[1] 

机构地区：[1]中国医科大学一院麻醉科,沈阳市110001

出　　处：《中华麻醉学杂志》1997年第9期527-529,共3页Chinese Journal of Anesthesiology

摘　　要：目的:比较Diethylamine/nitric oxide(DEA/NO)和硝普钠(SNP)行控制性降压时血流动力学的异同。方法:健康杂种犬(n=12只)麻醉后随机分为两组,分别输注0.001％DEA/NO或0.01％SNP,使平均动脉压(MAP)降至基础值的60％,并维持30分钟后停药,降压期间监测MAP、心率(HR)、中心静脉压(CVP)、平均肺动脉压(MPAP)、心输出量(CO)、及动脉血气、动脉血乳酸值、尿量的变化。结果:(1)降压期间两组动物HR、CVP及CO均无明显改变(P>0.05),MPAP轻度下降(P>0.05);(2)降压期间两组动物pH值未见改变(P>0.05),动脉血乳酸值无升高(P>0.05),尿量未减少(P>0.05)。结论:DEA/NO控制性降压时血流动力学改变与使用SNP相比无显著性差异。Objective: To compare hemodynamic effects of infusion of diethylamine/nitric oxide (DEA/NO)and sodium nitroprusside(SNP)during controlled hypotension. Method: General anesthesia was induced in dogs. The twelve healthy adult dogs were randomly assigned into one of two groups. 0.00l％ DEA/NO or 0.01％ SNP was infused to induce mean arterial pressure(MAP) to decrease to 60％ of baseline and be maintained for 30 min. During hypotension, MAP,central venous pressure (CVP), mean pulmonary artery pressure (MPAP)and cardiac output (CO) were measured and recorded. Arterial blood gas, blood lactate and urine output were also measured. Result: HR,CVP and CO were unchanged during hypotension period in both groups, MPAP decreased correspondently with MAP. There were no significantly changes in arterial blood gas,blood lactate and urine output in both groups during hypotension. Conclusion: Controlled hypotension achieved with infusion of DEA/NO has a rapid onset and short duration of action.The hemodynamics were similar to those of SNP.

关 键 词：二乙胺类 一氧化氮 硝普钠 降压 控制性 

分 类 号：R972.4[医药卫生—药品]