七氟醚对罗库溴铵量-效关系和恢复时相的影响  

Effects of sevoflurane on the dose-response relationship and the time-course of recovery of rocuronium

作　　者：薛富善[1] 廖旭[1] 佟世义[1] 刘建华[1] 安刚[1] 罗来葵[1] 

机构地区：[1]中国医学科学院中国协和医科大学整形外科医院麻醉科,北京市100041

出　　处：《中华麻醉学杂志》1997年第9期530-532,共3页Chinese Journal of Anesthesiology

基　　金：中国医学科学院中国协和医科大学政策性资助项目;编号954006

摘　　要：目的:研究七氟醚对罗库溴铵量-效关系和恢复时相的影响。方法:选择60例ASA Ⅰ级,年龄18～52岁,施择期整形外科手术的患者,随机分为对照组和七氟醚组。对照组用60％N_2O-O_2-硫喷妥钠维持麻醉,七氟醚组用N_2O-O_2-IMAC七氟醚维持麻醉。采用累积给药方法建立罗库溴铵的量-效关系曲线。结果:七氟醚能明显平行左移罗库溴铵的量-效关系曲线,与对照组相比,罗库溴铵在七氟醚组的ED_(50)、ED_(90)和ED_(95)分别降低31.0％、27.0％和25.0％。应用罗库溴铵400μg/kg后,其高峰作用时间、临床作用时间、恢复时间和体内作用时间在七氟醚组均明显延长。结论:七氟醚麻醉能明显增强罗库溴铵的神经肌肉阻滞效应,延长其作用时间。Objective: To evaluate the effects of sevoflurane on the dose-response relationship and on the timecourse of recovery of rocuronium. Method: Sixty patients,ASA grade Ⅰ,aged 18 to 52 years, undergoing elective plastic surgery,were included in this study. Patients were equally allocated randomly to either the control or the sevoflurane group. Anesthesia was maintained with 60％ N_2O-O_2-thiopental in the control group,and with 1 MAC sevofurane-N_2O-O_2 in the sevoflurane group. The dose-response relationship of rocuronium was established with a cumulative dosing regimen. Result: The dose response curve of rocuronium in the sevoflurane group was shifted to the left. The ED_(50),ED_(90) and ED_95 of rocuronium were decreased by 31％, 27％ and 25％, respectively in sevoflurane group as compared with those of the control group. Following an intravenous administration of rocuronium 400ug/kg,the duration of peak effect,duration of clinical relaxation,recovery index,and the total duration of action in the sevoflurane group were significantly prolonged vs. the control group. Conclusion: Sevoflurane can significantly enhance the neuromuscular blockade effect of rocuronium and prolong its duration of action.

关 键 词：罗库溴铵 药效动力学 七氟醚 

分 类 号：R614.21[医药卫生—麻醉学] R971.8[医药卫生—外科学]