扶正护脑胶囊对脑出血大鼠蓝斑和心肌组织去甲肾上腺素含量的影响  

Effect of Fuzhenghunao Capsule on NE of the Locus Ceruleus and Myocardial Tissues in Rats with Intracerebral Hemorrhage

作　　者：赵彦青[1] 王伟民[1] 申亚晖[1] 宋文翔[1] 

机构地区：[1]河南省中医院,河南郑州450002

出　　处：《中国中医药信息杂志》2008年第1期35-37,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家中医药管理局科研基金课题(00-01LP06)

摘　　要：目的观察扶正护脑胶囊对脑出血大鼠蓝斑和心肌组织去甲肾上腺素含量的影响。方法动物随机分为假手术组、模型组、扶正护脑组和安宫牛黄组,分别于术后6、24、72h3个时相点取材,采用高效液相色谱-电化学检测法测定蓝斑和心肌组织去甲肾上腺素的含量。结果术后各时间点蓝斑和心肌组织去甲肾上腺素的含量均显著升高,扶正护脑组和安宫牛黄组均能降低其含量。结论扶正护脑胶囊通过抑制蓝斑-去甲肾上腺素系统的激活,减轻脑出血后心肌的损伤。Objective To observe the effect of Fuzhenghunao capsule on NE of the locus ceruleus and myocardial tissues in rats with intracerebral hemorrhage. Methods 72 rats were randomly divided into 4 groups： sham, model, Fuzhenghunao and Angongniuhuang. The content of NE were tested by the high performance liquid phase-electrochemical method at 6 h, 24 h and 72 h of post-operation. Result NE was obviously increased in sham group, and decreased in two treatment groups. Conclusion Fuzhenghunao capsule could be used to inhibit the activation of locus ceruleus noradrenalin system and protect myocardial tissues by regulating NE content.

关 键 词：扶正护脑胶囊 去甲肾上腺素 蓝斑-去甲肾上腺素系统 大鼠 

分 类 号：R285.5[医药卫生—中药学]