盐酸戊乙奎醚治疗原发性痛经疗效观察  

Effects of penehyclidine hydrochloride on primary dysmenorrhea

作　　者：程良道[1] 程玉芬[2] 邓群[1] 周芸芸[3] 陈蒙蒙[1] 周群[1] 张冰[1] 

机构地区：[1]江西省妇幼保健院麻醉科,江西南昌330006 [2]江西省妇幼保健院妇科,江西南昌330006 [3]江西省妇幼保健院信息科,江西南昌330006

出　　处：《中国医药》2008年第1期8-9,共2页China Medicine

基　　金：基金项目：江西省卫生厅科研基金资助项目（20041129）

摘　　要：目的观察盐酸戊乙奎醚（长托宁）治疗原发性痛经的，临床效果。方法70例中、重度原发性痛经患者。随机分为2组：治疗组50例，应用盐酸戊乙奎醚治疗，初治者：盐酸戊乙奎醚0．5mg肌肉注射，早晚各1次：效差者：盐酸戊乙奎醚0．8mg肌肉注射，早晚各1次。对照组20例，用强痛定50mg肌肉注射治疗。早晚各1次。按“痛经程度划分标准”分级，作为对痛经治疗疗效的评估标准。并建档进行远期跟踪观察。结果治疗组37例治疗1-2次症状基本消失，评分（3．6±1．1）分属显效；10例患者治疗一疗程后基本治愈，评分（5．0±1．9）分属有效；有3例患者治疗时症状改善，但反复发作，属效差。对照组用强痛定治疗后。显效3例，有效5例，无效12例。治疗组总有效率为94％，对照组为40％，组间比较具有统计学意义（P〈0．01）。结论盐酸戊乙奎醚用于治疗原发性痛经效果显著，明显优于强痛定。Objective To investigate the effects of Penehyclidine Hydrochloride （PH） on primary dysmenorrhea. Methods Seventy moderate heavy primary dysmenorrhea female patients were enrolled in this study, divided into two groups randomly. Among them, 50 patients receive PH and 20 receive Bucinnazine Hydroehloride （BH）. Specifically, in PH group, some were given the treatment for the first time （PH 0.5 mg, twice daily）; others had been treated with PH but with poor effect （PH 0.8mg, twice daily）. The BH group, as the comparison group, received 50mg, twice daily. The results were assessed according to the grading of the Ministry of Health, China. Results In PH group, 37 women scored under 5 after using PH （0. 5mg） ; 10 were between 5 and 10 after two menstrual cycles; symptoms were improved in 3 patients, but still relapsed. In BH group, 3 patients had significant effects, 5 showed effective and 12 had no effect. The PH group＇s effective rate （94%） was significantly higher than the BH group （40%） （P 〈0. 01 ）. Conclusion PH can be used for the painful menstruation treatment and shows a better effect is than BH.

关 键 词：原发性痛经 盐酸戊乙奎醚 

分 类 号：R711.51[医药卫生—妇产科学]