2型糖尿病伴冠心病患者胰岛素抵抗与游离脂肪酸关系研究  

Relationship between insulin resistance and free fatty acids in patients of type two diabetes mellitus with coronary heart disease

作　　者：李斌[1] 余绮玲[2] 钟向红[3] 

机构地区：[1]广州医学院第三附属医院内分泌科,广州510150 [2]广州市第一人民医院内分泌科,广州510180 [3]广州医学院第三附属医院心内科,广州510150

出　　处：《临床荟萃》2008年第1期13-15,共3页Clinical Focus

摘　　要：目的了解2型糖尿病伴冠心病患者胰岛素抵抗(IR)与游离脂肪酸(FFA)的关系。方法将2型糖尿病伴冠心病患者39例、单纯2型糖尿病患者42例、单纯冠心病患者40例、健康人群42例为研究对象。检测所有对象的FFA、胰岛素敏感性指数(ISI)以及总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)等指标。结果2型糖尿病伴冠心病组的FFA、ISI、TC、TG和LDL-C分别为(697.58±45.12)μmol/L、-4.99±0.12、(6.72±1.26)mmol/L、(3.14±0.98)mmol/L、(3.56±0.99)mmol/L,FFA、TC、TG、LDL-C等各项指标均以2型糖尿病伴冠心病组高于其余各组(均P<0.05);ISI则以2型糖尿病并冠心病组低于其余各组(均P<0.05);将2型糖尿病伴冠心病组的FFA与ISI、血脂3项指标作相关性分析,结果FFA与ISI呈负相关(r=-0.773,P<0.05),与TC、TG、LDL-C呈正相关(分别为r=0.791,0.816,0.873,均P<0.05)。结论在2型糖尿病并冠心病患者中,FFA升高与IR是并存的,并且存在明显相关关系,二者在疾病的发生发展中均具有重要的作用。Objective To explore the relationship between insulin resistance（IR） and free fatty acids（FFA） in patients with type two diabetes mellitus and coronary heart disease（CHD）. Methods The patients of type two diabetes mellitus with CHD （39 cases） ,type two diabetes mellitus alone （42 cases） ,CHD alone （40 cases） were selected as case groups,while the healthy individuals （42 cases） were selected as control group. FFA, insulin-sensitivity index（ISI）, total cholesterol（TC）, triglyceride（TG）, low density lipoprotein-cholesterol（LDL-C） were tested for each subject. Results The levels of FFA,ISI,TC,TG and LDL-C in type two diabetes mellitus with CHD were （697.58±45.12） μmol/L, -4.99±0.12, （6.72 ± 1.26） mmol/L, （3.14 ± 0.98） mmol/L, （3.56 ± 0.99） mmol/L, respectrvely. The levels of FFA,TC, TG,LDL-C of the type two diabetes mellitus companied with CHD group were higher than those of other three groups （ P 〈 0.05 ） . However , ISI level of the former group was lower than that of other three groups （allP 〈0.05）. According to the data of the type two diabetes mellitus with CHD group, there existed negative correlation between FFA and ISI（ r = -0. 773, P 〈 0.05）, while there existed positive correlation between FFA and TC,TG,LDL-C（ r =0. 791,0. 816,0. 873,all P 〈0.05）. Conclusion In patients of type two diabetes mellitus with CHD,there existed clear correlation between higher FFA and more IR. Both factors play a very important role in the development of the disease.

关 键 词：糖尿病 2型 冠状动脉疾病 胰岛素 

分 类 号：R587.1[医药卫生—内分泌]