OPV疫苗液体剂型稳定性影响因素分析  

Stabilities of live attenuated oral poliomyelitis vaccine

作　　者：宋霞[1] 段维国[1] 全文琦[1] 黄铠[1] 张晓丽[1] 张云昆[1] 谢明学[1] 谢忠平[1] 

机构地区：[1]中国医学科学院北京协和医学院医学生物学研究所,云南昆明650118

出　　处：《云南大学学报（自然科学版）》2008年第1期98-100,108,共4页Journal of Yunnan University(Natural Sciences Edition)

基　　金：云南省科技创新人才引培项目(2002PY11)

摘　　要：分析了温度、反复冻融、冷链运输过程对口服脊髓灰质炎减毒活疫苗(OPV)滴度的影响,检测结果显示OPV分别在37℃条件下放置3 d,25℃放置14 d,-20℃放置36个月、反复冻化35次,感染性滴度均无明显变化.在冷链条件下运输,其感染性滴度无明显变化.液体剂型的稳定性优于糖丸剂型(t=3.204 3,P<0.01).The influences of temperature, freezing and melting repeatedly and cold-chain transportation on oral polio vaccine （OPV） were analyzed. The results indicated that the titers of OPV had no obvious changes after being put at 37℃ for 3 days,25 ℃ for 14 days and - 20℃ for 36 months,and being freezed and melted for 35 times, respectively. The titers had no obvious changes under the cold-chain transportation. The stability of the liquid form is better than the dragee candy form （ t = 3. 204 3, P 〈 0. 01）.

关 键 词：脊髓灰质炎病毒 减毒活疫苗 稳定性 

分 类 号：Q819[生物学—生物工程]