N-硝基-N,N′-二苯基脲衍生物的合成及其双功效活性  

Synthesis and Double-function of Seven N-Nitro-N,N′-diphenyl Urea Derivatives

作　　者：熊金苹[1] 陈长水[1] 李雪刚[1] 许洪涛[1] 

机构地区：[1]华中农业大学理学院化学系,武汉430070

出　　处：《应用化学》2008年第1期17-21,共5页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金资助项目(39770845)

摘　　要：采用固体光气法合成了7个新的N-硝基苯基脲类化合物，收率为74％～88％，通过IR、GC—MS、^1H NMR谱及元素分析测试技术对其进行了结构表征；分析了这些化合物对水稻和稗草的生长及抑制的双功效活性。结果表明，7个化合物表现出一定的植物生长调节活性和除草活性，其巾化合物c对水稻成活、茎长、根长、鲜重分别表现出6．66％、0．89％、3．18％、0.3％的促进活性，对稗草成活和鲜重分别表现出55％和42．56％的抑制活性。化合物C有望开发成一种新的双效素。讨论了各化合物的生物活性与其分子结构之间的相关性。Seven novel N,N-nitrophenyl urea compounds were synthesized in yields of 74% ～88% via nonphosgene method, and their structures were confirmed by IR, GC-MS, ^1H NMR and elemental analysis. Their primary double-function activity was screened on Oryza sativa and Echinochloa crusgalli L. The seven compounds exhibited certain plant growth regulating activity and herbicidal activity. Among those compounds, compound C exhibited 6.66% , 0. 89% , 3.18% , and 0. 3% growth regulating activities to living, stem length, root length, and fresh weight of Oryza sativa and 55% , and 42.56% inhibitory rates against living and fresh weight of Echinochloa crusgalli L, showing the potential of double-function. In addition, the correlations between biological activities and molecular structures of the compounds were discussed.

关 键 词：N-硝基脲 合成 双功效 生物活性 

分 类 号：O625.6[理学—有机化学]