45岁以下女性冠心病患者危险因素及冠状动脉造影特点分析  

Coronary Risk Factors and Angiographic Characterization in Young Women ≤45 Years Old with Coronary Heart Disease

作　　者：郑昕[1] 李建军[1] 郭远林[1] 慕朝伟[1] 张朝阳[1] 高展[1] 戴军[1] 

机构地区：[1]中国医学科学院阜外心血管病医院冠心病诊治中心,北京市100037

出　　处：《中国动脉硬化杂志》2007年第10期769-772,共4页Chinese Journal of Arteriosclerosis

摘　　要：目的探讨45岁以下女性冠心病患者的发病特点。方法以45岁以上女性冠心病患者(n=119)为对照,回顾性分析45岁以下女性冠心病患者(n=123)的危险因素、冠状动脉造影特点和血运重建情况。结果45岁以下女性冠心病组合并高血压64例(52.0%),糖尿病21例(17.0%),高胆固醇血症32例(26.0%),均明显低于45岁以上女性冠心病组(P<0.05);45岁以下女性冠心病组有心肌梗死病史43例(35.0%),与45岁以上女性冠心病组没有显著差别。与45岁以上女性冠心病组相比,冠状动脉造影零支病变和单支病变多见,三支病变少见,接受药物治疗和单支血管介入治疗者多见(P均<0.05)。结论45岁以下女性冠心病患者危险因素相对较少,高血压是重要的危险因素。冠状动脉造影显示病变相对局限,心肌梗死的发生率没有降低,应积极防治。Aim To investigate clinical characteristic of women ≤ 45 years old with coronary heart disease. Methods Coronary risk factors, angiographic characterization and revascularization of young women ≤ 45 years old （group A, n = 123） were retrospectively analyzed, compared with that of women 〉 45 years old （group B, n = 119）. Results Among group A, 64 （52.0% ） patients had hypertension, 21 （17.0% ） patients had diabetes, 32 （26.0% ） patients had hypercholesterolemia, each of which was higher than that of group B （ P 〈 0.05） ; 43 （35.0% ） patients had a history of myocardial infarction, which was similar to group B. Group A were more likely to have angiographically zero and single-vessel disease （ P 〈 0.05）, and less likdy to have three-vessel disease （ P 〈 0.05） compared with group B. Drug therapy and single- vessel coronary pereutaneous intervention were more often performed for group A than group B （ P 〈 0.05 ）. Conclusions Women ≤ 45 years old had relatively less coronary risk factors and less extensive disease, and hypertension was an important risk factor. No lower morbidity of myocardial infarction was revealed. More attention should be paid on prevention and therapeutic management of young women with coronary heart disease.

关 键 词：内科学 冠心病 危险因素 冠状动脉造影 女性 

分 类 号：R5[医药卫生—内科学]