高密度脂蛋白与冠状动脉支架植入术后再狭窄的关系  

The Relationship Between High Density Lipoprotein Cholesterol and Intracoronary In-stent Restenosis

作　　者：丁旻珺[1] 刘建平[1] 江柳月[1] 李晓燕[1] 

机构地区：[1]上海交通大学医学院附属仁济医院心内科,上海市200127

出　　处：《中国动脉硬化杂志》2007年第10期783-785,共3页Chinese Journal of Arteriosclerosis

摘　　要：目的探讨再次入院造影复查时血高密度脂蛋白胆固醇水平与冠状动脉支架植入术后再狭窄的关系。方法根据再次冠状动脉造影复查结果,将370例行冠状动脉内支架术并随访造影结果的患者分为再狭窄组与非再狭窄组,对两组临床情况及生物化学指标进行回顾性分析。结果370例患者中有487支靶血管置入支架,94例患者的123支靶血管发生再狭窄。单因素分析显示再狭窄组的高密度脂蛋白胆固醇水平显著低于非再狭窄组,差异有显著性(P<0.05);二分类多因素Logistic回归分析显示低高密度脂蛋白胆固醇水平(高密度脂蛋白胆固醇≤1.04mmol/L)为冠状动脉内再狭窄的独立危险因素。结论提示血高密度脂蛋白胆固醇水平与冠状动脉支架植入术后再狭窄密切相关。Aim To evaluate the relationship between high-density lipeprotein cholesterol and intracoronary in-stent restenosis during angiographie follow-up, Methods 370 patients were successfully underwent coronary stem implantation with a follow-up study of angiography, They were divided into restenosis group and non-restenesis group. In-stem restenosis was defined as luminal diameter narrowing of intraeronary stem by 50% or greater. Results In 370 patients,487 coronary stents were implanted. In-stent restenosis occurred in 123 lesions of 94 patients. Serum concentration of high density lipoprotein in in-stent restenosis group was significant higher than that in non in-stent restenosis group（ P 〈 0.05）, Multivariate logistic regression analysis revealed that low high density lipoprotein was an independent risk factor of in-stent restenosis. There is a close relationship between serum high density lipoprotein and in-stent restenosis. The occurrence of in-stent restenosis may be reduced by regulating serum high density lipoprotein.

关 键 词：内科学 冠状动脉疾病 支架植入 再狭窄 高密度脂蛋白胆固醇 血管成形术 

分 类 号：R5[医药卫生—内科学]