LINK BETWEEN OXIDATIVE STRESS AND INSULIN RESISTANCE  

作　　者：Lan-fang Li Jian Li 

机构地区：[1]Key Laboratory of Geriatrics of Ministry of Health, Beijing Institute of Geriatrics, Beijing Hospital, Ministry of Health, Beijing 100730

出　　处：《Chinese Medical Sciences Journal》2007年第4期254-259,共6页中国医学科学杂志（英文版）

基　　金：Supported by grant from the National Basic Research Program (973Program) (2006CB503903)

摘　　要：Many studies on oxidative stress,insulin resistance,and antioxidant treatment have shown that increased oxidative stress may accelerate the development of diabetic complications through the excessive glucose and free fatty acids metabolism in diabetic and insulin-resistant states.Many pathogenic mechanisms such as insulin receptor substrate phosphorylation are involved in insulin resistance induced by oxidative stress.And antioxidant treatments can show benefits in animal models of diabetes mellitus and insulin resistance.However,negative evidence from large clinical trials suggests that new and more powerful antioxidants need to be studied to demonstrate whether antioxidants can be effective in treating diabetic complications.Furthermore,it appears that oxidative stress is only one of the factors contributing to diabetic complications.Thus,antioxidant treatment would most likely be more effective if it were coupled with other treatments for diabetic complications.

关 键 词：insulin resistance oxidative stress diabetes mellitus 

分 类 号：R587.1[医药卫生—内分泌]