盐酸环丙沙星-聚氰基丙烯酸正丁酯纳米溶胶的制备  

Preparation of ciprofloxacin hydrochloride polybutylcyanocrylate nanoparticles

作　　者：张向荣[1] 王晶[1] 周海波[1] 张萱怡[1] 李三鸣[1] 潘卫三[1] 

机构地区：[1]沈阳药科大学药学院,沈阳110016

出　　处：《中国新药杂志》2007年第24期2054-2056,共3页Chinese Journal of New Drugs

摘　　要：目的:制备盐酸环丙沙星-聚氰基丙烯酸正丁酯纳米溶胶,并对其处方因素进行考察。方法:以氰基丙烯酸正丁酯为载体材料,采用乳化聚合法制备盐酸环丙沙星-聚氰基丙烯酸正丁酯纳米溶胶,以粒径、外观为主要指标,用单因素方法优化处方,得到二步法制备纳米溶胶的条件和工艺。结果:制备的纳米溶胶的平均粒径为(82.6±15)nm,包封率为61.9%,载药量为34.2%(g/g),平均Zeta电位为(-25.1±9.92)mV。结论:本实验制备的盐酸环丙沙星-聚氰基丙烯酸正丁酯纳米溶胶的粒径小,分布窄,稳定性好。Objective ：To prepare ciprofloxacin hydrochioride polybutylcyanocrylate nanoparticles （CIP-PBCA-NP）. Methods： CIP-PBCA-NP was prepared by butylcyanocrylate with emulsification-polymerization. An optimum condition was established by single factor test and with the entrapment efficiency,with the quantity of load-drug and size distribution as the main test standard. Results：The nanoparticles featured the mean diameter of （82.6 ± 15 ）nm,the mean drug loading of 34, 2% ,the mean encapsulation efficiency of 61.9% , the mean Zeta potential was （ - 25.1 ± 9.92 ） mV. Conclusion ： The optimal preparation procedure of CIP-PBCA-NP was achievable and stable.

关 键 词：盐酸环丙沙星 氰基丙烯酸正丁酯 纳米溶胶 

分 类 号：R943.42[医药卫生—药剂学] R978.26[医药卫生—药学]