等效剂量舒芬太尼与芬太尼全麻术后静脉自控镇痛的临床效果比较  

Comparison of Sufentanil to Fentanil on patient-control intravenous analgesia after general anesthesia

作　　者：熊添[1] 李家新[1] 杨昭云[2] 

机构地区：[1]北京航天总医院,北京100076 [2]中南大学湘雅附属第二医院,湖南长沙430001

出　　处：《实用医技杂志》2007年第31期4260-4261,共2页Journal of Practical Medical Techniques

摘　　要：目的:比较舒芬太尼与芬太尼对全麻术后静脉自控镇痛(PCIA)的临床效果及副作用发生率。方法:选择择期全麻手术患者60例,ASAⅠ级～Ⅱ级。随机分为两组,每组30例。结束前30min使用PCIA(背景剂量2.5 ml/h,PCA 5ml/次,镇定时间8min)。Ⅰ组芬太尼4mg/ml;Ⅱ组舒芬太尼0.8mg/ml。观察术后2h、4h、8h、12h、24 h、48h镇痛(VAS)和镇静评分,记录血压、脉搏、呼吸频率的变化及恶心、呕吐等不良反应。结果:两组患者均镇痛良好,舒芬太尼组各时点的镇痛评分最低,与芬太尼组相比差异有显著性(P<0.05)。镇静效果差异无显著性(P>0.05);两组间不良反应发生率差异无显著性(P>0.05)。结论:舒芬太尼的镇痛效果是安全、有效、可行的,可在临床推广。Objective To evaluate the value and side effects of patient-control intravenous analgesia （PCIA） with sufentanil and fentanil after general anesthesia. Methods 60 cases graded ASA Ⅰ - Ⅱ were randomly divided into two groups. Before 30 minutes at the end of operation, Ⅰ group received with 4 mg/ml fentanil; Ⅱ group received with 0.8 mg/ml sufentanil, PCIA include background 2.5 ml/h and bolus of 5 ml with lockout-time 8 minutes, and the outcomes were evaluated by recording the patients ,visualanalogscale（VAS） at 2 h ,4 h ,8 h, 12 h,24 h ,48 h after operation. The change of pressure,pulse , breathing and side effects such as nausea and vomiting were also recorded. Results Two groups showed good pain relief. In the Ⅱ group, VAS were all lower than that in the Ⅰ group （ P 〈 0.05 ）. But there was no significant difference between Ⅰ and Ⅱ group in patients（ P 〉0.05）. There were no differences in side effects in two groups （P 〉 0.05）. Conclusion Postoperative analgesia with sufentanil was proved to be a good method to manage postoperative pain after general anesthesia for patients.

关 键 词：舒芬太尼 芬太尼 静脉自控镇痛 

分 类 号：R614[医药卫生—麻醉学]