盐酸氨基葡萄糖治疗膝退行性骨性关节炎的临床观察  

THERAPEUTIC RESULTS OF GLUCOSAMINE HYDROCHLORIDE FOR KNEE DEGENERATIVE OSTEOARTHRITIS

作　　者：冮相保[1] 高李侠[2] 

机构地区：[1]武汉市中西医结合医院骨科,武汉430000 [2]湖北中医学院

出　　处：《中国修复重建外科杂志》2008年第1期29-31,共3页Chinese Journal of Reparative and Reconstructive Surgery

摘　　要：目的评价盐酸氨基葡萄糖治疗膝退行性骨性关节炎(degenerative osteoarthritis,DOA)的临床疗效。方法2006年2月-2007年1月,采用盐酸氨基葡萄糖治疗60例膝DOA患者。男15例,女45例;年龄41～67岁,平均57.5岁。病程6个月～3年。每日2次,每次750mg,6周为1个疗程,4个月后重复1个疗程。所有患者经过2个疗程治疗后,采用国际DOA的评分标准——Lequesne指数评定膝关节休息痛、运动痛、压痛、关节活动度、晨僵及行走能力。结果治疗期间3例患者产生不良反应,发生率为5%,未作特殊处理后恢复。60例患者均获随访8～11个月,平均9.6个月。经治疗后,31例DOA各种临床症状完全消失,治愈率为51.7%;27例临床症状有不同程度减轻,好转率为45.0%;总有效率为96.7%。膝关节休息痛、运动痛、压痛、关节活动度、晨僵及行走能力治疗后评分分别为(0.5±0.2)(、0.7±0.4)、(0.8±0.3)、(0.9±0.4)、(0.6±0.3)及(0.9±0.4)分,治疗前各项评分为(1.6±0.5)、(2.1±0.4)、(2.2±0.5)、(1.8±0.6)、(1.7±0.4)及(2.0±0.4)分,治疗前后比较差异有统计学意义(P<0.01)。结论盐酸氨基葡萄糖对治疗膝DOA具有缓解临床症状,改善关节功能的作用。Objective To evaluate the results of glucosamine hydrochloride in the treatment of knee degenerative osteoarthritis （DOA） . Methods From February 2006 to January 2007, 60 patients with knee DOA were treated with glucosamine hydrochloride, including 15 males and 45 females. The ages of patients ranged from 41 to 67 years with an average age of 57.5 years. The disease course ranged from 6 months to 3 years. Oral glucosamine hydrochloride was given twice a day, each 750 mg, for a 6-week course of treatment; another course of treatment was repeated after 4 months. After two courses of treatment, the international standard DOA score of Lequesne index was used to evaluate the rest of knee pain, sports pain, tenderness, joints activity, morning stiffness and walking ability. Results All 60 patients finished treatment, various clinical symptoms for DOA disappeared completely in 31 cases and subsided in 27 cases; the cure rate was 51.7% and the total response rate was 96.7%. The scores of rest pain, sport pain, tenderness, joints activity, morning stiffness and the ability to walk for knee after treatment were 0.5±0.2, 0.7±0.4, 0.8±0.3, 0.9±0.4, 0.6±0.3 and 0.9±0.4, showing statistically significant differences （P 〈 0.01） when compared with preoperation （1.6±0.5, 2.1±0.4, 2.2±0.5, 1.8±0.6, 1.7±0.4 and 2.0±0.4）. Adverse effect occurred in 3 cases （5%） and the patients recovered without special treatment. Conclusion Glucosamine hydrochloride can cure knee DOA with symptom-rel ieving and joint function-improving action.

关 键 词：膝骨性关节炎 盐酸氨基葡萄糖 临床疗效 

分 类 号：R684.3[医药卫生—骨科学] R453[医药卫生—外科学]