黄芪总黄酮对急性心肌梗死心室肌细胞钠电流的作用  

The effects of totalflavonoids of astragalus(TFA) on the sodium current of the ventricular myocytes after the acute myocardial infarction

作　　者：包吉日木图[1] 赵明[1] 包伍叶[1] 

机构地区：[1]内蒙古民族大学附属医院,通辽市028000

出　　处：《中国心血管病研究》2008年第1期59-61,共3页Chinese Journal of Cardiovascular Research

摘　　要：目的探讨黄芪总黄酮(TFA)对急性心肌梗死(AMI)后大鼠心室肌细胞钠电流(ⅠNa)的影响。方法大鼠开胸左前降支结扎造成AMI,酶解分离心室肌细胞,采用全细胞膜片钳记录技术记录左前降支供血区心外膜细胞的ⅠNa。结果应用TFA(20mg/kg)后与AMI组比较,ⅠNa峰值从(-4.79±1.88)nA下降到(-2.74±1.67)nA,差异有统计学意义(P<0.01,n=6)。结论TFA可显著降低AMI大鼠心室肌细胞ⅠNa的幅值。Objective To study the effect of totalflavonoids of astragalus （TFA） on the sodium current of rat isolated ventricular myocytes after the acute myocardial infarction. Methods Whole cell patch clamp technique was applied to record the sodium current of rat isolated ventricular myocytes from ischemic zone adjacent to infarcted area. Results Ⅰ Na of TFA（20 mg/kg）decreased from （-4.79±1.88）nA to （-2.74±1.67）nA, there is significant difference compared to the acute myocardial infarction group（P〈0.01 ,n=6）.Conclusion The above resuhs suggested that TFA inhibit the sodium current of rat isolated ventricular myocytes after the acute myocardial infarction remarkably.

关 键 词：黄芪属植物 黄酮类 心室 心肌 心肌梗塞 钠 电子学 

分 类 号：R541.4[医药卫生—心血管疾病] Q95-33[医药卫生—内科学]