医学研究中的新工具——ABC家族  

A New Tool for Medical Research——ATP-Binding Cassette Transporter Families

作　　者：李高鹏[1] 叶露[2] 陈孝平[1] 

机构地区：[1]华中科技大学同济医院肝脏外科中心,武汉430030 [2]华中科技大学同济医院感染科心,武汉430030

出　　处：《中国普外基础与临床杂志》2008年第1期74-76,共3页Chinese Journal of Bases and Clinics In General Surgery

基　　金：卫生部临床学科重点项目(编号:2001-321)~~

摘　　要：目的介绍目前ATP结合盒式蛋白(ATP-binding cassette,ABC)家族在医学研究中新的应用进展。方法采用文献回顾的方法对ABC家族在科学研究中的应用进展进行综述。结果ABC家族主要从事细胞内、外的物质转运,在多种疾病的诊断、治疗等多方面具有重要意义。结论ABC家族是医学研究中很有前途的新工具。Objective To review the application advancements of ATP-binding cassette （ABC） transporter in medical research. Methods Relevant literatures about the applications of ABC families in medical research were reviewed. Results ABC families mainly took roles in transporting substances across cell membrane. Some of them were useful for the prediction of drug resistance and the prognosis of malignant tumors. Others were targets for mo- lecular researches. Their expressions or mutations might be related with the occurrence of diseases. Conclusion ABC families are very important in the diagnosis and therapy for diseases. Thus they are very promising tools for fu- ture medical research.

关 键 词：ATP结合盒式蛋白家族 多药耐药 干细胞 

分 类 号：R341[医药卫生—基础医学]