早产儿视网膜功能的全视野闪光视网膜电图检查  

Examination of full-field flash electroretinogram for retinal function of patients with retinopathy of prematurity

作　　者：陈红玲[1] 吴德正[1] 张国明[2] 黄时洲[1] 刘彩娇[1] 关天芹[1] 

机构地区：[1]中山大学中山眼科中心、中山大学眼科学国家重点实验室,广州510060 [2]深圳市眼科医院

出　　处：《中华眼底病杂志》2008年第1期23-25,共3页Chinese Journal of Ocular Fundus Diseases

摘　　要：目的观察早产儿视网膜功能变化特征。方法对78例4～5个月婴儿在口服镇静剂熟睡后进行全视野闪光视网膜电图（ERG）检查，测量各项反应的a波和b波的振幅和隐含期，以评价未成熟儿的视网膜功能。78例156只眼中，健康足月产儿33例66只眼，健康早产儿25例50只眼，早产儿视网膜病变（ROP）患儿20例40只眼。结果所有足月产儿和健康早产儿都可以记录到明显的ERG波形。足月产儿的标准混合反应b波振幅为388．7μV，健康早产儿的标准混合反应b波振幅为336．7μV，分别为正常成人混合反应b波振幅的64．4％和55．6％。ROP患儿中，20只眼记录不到波形，其余20只眼的标准混合反应b波振幅为183．8μV，和足月产儿相比，隐含期也显著延迟。健康早产儿的ERG振幅较足月产儿轻度降低，差异有统计学意义。结论出生后视网膜还处于不断成熟发育过程中，健康足月产儿的ERG尚未达到正常成人的水平；早产儿视网膜发育程度较足月儿慢，不论是健康早产儿还是ROP患儿，其ERG均不及健康足月产儿。因此ERG检查是评价早产儿视网膜功能的有效方法。Objective To observe the retinal function of infants with retinopathy of prematurity （ROP）. Methods A total of 78 infants （156 eyes） aged from 4-5 months underwent full-field flash electroretinogram （ERG） examination. The amplitude and implicit time of a- and b-wave of ERG were detected to evaluate the infants＇ retinal function. Seventy-eight infants （156 eyes） included 33 healthy and full-term infants （66 eyes）, 25 healthy premature children （50 eyes）, and 20 infants （40 eyes） with ROP. Results Obvious ERG waveforms were recorded in all the full-term and healthy premature children. Amplitude of combined b-wave was 388. 7 μV in full-term infants and 336. 7 μV in healthy premature children, which was 64. 4% and 55.6% of that of the healthy adults respectively. In infants with ROP, ERG was nonrecordable in 20 eyes （50%）; amplitude of combined b-wave was 183.8 μin the other 20, whose implicit time delayed obviously compared with that of full-term infants. The amplitude of ERG of healthy premature infants decreased significantly compared with that of the full-term infants. Conclusions Retina keeps growing after birth. ERG of healthy full-term children is not as developed as those of adults. The progress of retinal maturation in infants with ROP is slower than that in the full-term infants. ERG examination is an effective method in evaluating retinal function of infants with ROP.

关 键 词：视力试验 婴儿 早产/生理学 视网膜电描记术 

分 类 号：R686[医药卫生—骨科学]