注射用加替沙星与酚磺乙胺注射液的配伍稳定性考察  

Compatible Stability of Gatifloxacin for Injection with Etamsylate Injection

作　　者：杨继章[1] 赵增仁[1] 刘瑞琴[1] 杨树民[1] 

机构地区：[1]河北医科大学第一医院,石家庄市050031

出　　处：《中国药房》2008年第2期116-118,共3页China Pharmacy

基　　金：河北省2004年医学科学研究重点课题(04177)

摘　　要：目的:考察注射用加替沙星与酚磺乙胺注射液在0.9%氯化钠注射液和5%葡萄糖注射液中配伍的稳定性。方法:在室温((20±1)℃)下,观察8h内配伍液在0.9%氯化钠注射液和5%葡萄糖注射液中的外观,测定pH值及考察紫外光谱的变化,并用紫外双波长分光光度法测定加替沙星和酚磺乙胺的含量。结果:2药配伍后,8h内的pH值及外观均无明显变化,在0.9%氯化钠注射液中8h内以及在5%葡萄糖注射液中6h内,配伍液的含量无明显变化。结论:加替沙星与酚磺乙胺注射液在0.9%氯化钠注射液和5%葡萄糖注射液中配伍稳定。OBJECTIVE ：To study the compatibility of gatifloxacin for chloride injection and 5% glucose injection .METHODS：The appearance of ylate injection in 0.9% sodium chloride injection and 5% glucose injection was observed, with its pH measured and ultraviolet spectra observed.The injection with etamsylate injection in 0.9% sodium the mixture of gatifloxacin for injection with etamsat room temperature, i .e. （20 ±1）℃ within 8 hours contents of gatifloxacin and etamsylate were determined by a dual ultraviolet spectrophotometry.RESULTS： No significant change was noted for the mixture within 8 h in pH and appearance, and the contents of gatifloxacin and etamsylate within 8 h in 0.9% sodium chloride iniection or within 6 h in 5% glucose injection showed no obvious change.CONCLUSION： Gatifloxacin for injection can be mixed with etamsylate injection in 0.9% sodium chloride injection or 5% glucose iniection.

关 键 词：注射用加替沙星 酚磺乙胺注射液 配伍 稳定性 紫外分光光度法 

分 类 号：R969.2[医药卫生—药理学]