养心颗粒对冠心病快速型心律失常模型兔血浆一氧化氮及前列环素含量的影响  

Effect of Yangxin Granule on NO and PGI_2 Content in Coronary Heart Disease with Tachyarrhythmia

作　　者：徐倩[1] 周亚滨 吴桐菲[1] 赵艳茹[1] 

机构地区：[1]黑龙江中医药大学 [2]黑龙江中药大学附属第一医院

出　　处：《中西医结合心脑血管病杂志》2008年第1期40-41,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：黑龙江省教育厅基金资助项目(No.11511375)

摘　　要：目的观察养心颗粒对冠心病快速型心律失常模型兔血浆一氧化氮(NO)及前列环素(PGI2)含量的影响,探讨其防治冠心病快速型心律失常的作用机制。方法用高脂饮食喂养并结合静脉注射肾上腺素复制冠心病快速型心律失常模型,并随机分为模型组、养心颗粒治疗组、养心颗粒防治组、胺碘酮治疗组,并另取7只做为空白组,测定各组家兔NO及PGI2含量。结果模型组、养心颗粒治疗组、胺碘酮治疗组与空白组比较,家兔血浆NO及PGI2含量均显著降低(P<0.01);养心颗粒防治组与模型组比较,家兔血浆NO及PGI2含量均显著提高(P<0.05)。结论用高脂饮食喂养家兔并结合静脉注射肾上腺素可以复制冠心病快速型心律失常动物模型,与人类冠心病快速型心律失常相近似;以益气养心安神为立法组成的养心颗粒能够增加NO的合成和PGI2的含量,进而改善内皮功能,这可能是其防治冠心病心律失常的作用机制之一。Objective To analyze the effects of Yangxin Granule on plasma NO and the PGI2 content in coronary heart disease （CHD） with arrhythmia model and its mechanism. Methods Rabbits were divided randomly into model group, treatment group, prevention group, amiodarone group and control group. The NO and PGI2 content were tested. Results Compared with control group, plasma NO and PGI2 content in model group, Yangxin granule group and amiodarone group decreased（ P 〈 0.01 ）. Compared with model group, plasma NO and PGI2 contend in Yangxin Granule group raised （ P 〈 0.01 ）. Conclusion Yangxin Granule could increase the synthesis of NO and PGI2 content and improve endothelial cell function to prevent arrhythmia.

关 键 词：养心颗粒 一氧化氮 前列环素 

分 类 号：R285.5[医药卫生—中药学]