D二聚体定量检测在肺部疾病的意义  

Significance of D-dimer concentration test in lung disease

作　　者：陈渝宁[1] 孟冬娅[1] 方秀菊[1] 

机构地区：[1]沈阳军区总医院检验科,沈阳市110015

出　　处：《实用诊断与治疗杂志》2008年第1期4-5,共2页Journal of Practical Diagnosis and Therapy

摘　　要：目的:通过对肺部疾病患者D二聚体的检测,探讨该指标与疾病的关系及意义。方法:患者组284例,各种肺部疾患均经临床确诊。对照组30例,为排除心脑血管疾病、糖尿病、高脂血症等疾病的健康人。Liatest免疫法D二聚体定量(D-dimer)用STAGO STA Compact全自动凝血仪检测。结果:慢性支气管炎D-dimer(1.14±0.92)μg/mL;肺炎(2.09±1.31)μg/mL;肺心病(1.34±1.04)μg/mL;肺栓塞(2.53±1.43)μg/mL;肺癌(2.26±1.24)μg/mL明显高于对照组(0.31±0.25)(P<0.01)。肺癌转移组(n=45)D-dimer明显高于肺癌局限组(n=74)(2.96±1.51)μg/mLvs(1.32±1.03)μg/mL,P<0.01。结论:肺部疾病患者均有不同程度继发纤溶亢进,肺栓塞和肺癌D-dimer高于其他肺部良性疾病。提示凝血及纤溶的异常在肺部炎性疾病及肿瘤的发生和发展中起重要的作用。Liatest法检测D-dimer具有快速、敏感和自动化的特点,有助于临床对肺栓塞患者的筛选。Objective To explore the significance and the association between variations of D-dimer and lung disease.Methods There were 284 patients in the patient group including 52 chronic bronchitis,44 pneumonia,32 cor pulmonale,47 pulmonary embolism and 119 lung cancer.The other 30 healthy controls were as control group.D-dimer was detected in all patients and 30 healthy control with Liatest method.Results D-dimer concentration was significantly higher in the patients with distant metastasis than in those without metastasis（P〈0.01）.Conclusion D-dimer concentration is abnormal in the above patients.It is indicated that there is an increase of D-dimer in patients with lung disease.It plays an important role in the screening of pulmonary embolism.

关 键 词：慢性支气管炎 肺炎 肺心病 肺栓塞 肺癌 D二聚体 

分 类 号：R563[医药卫生—呼吸系统]