荧光胃液分析胃癌癌前病变与胃液中幽门螺杆菌感染的关系  

The relation between autofluorescence spectrum of gastric juice and Helicobacter pylori in precancerous lesion of gastric cancer

作　　者：董琳[1] 王铁武[1] 施明国[1] 

机构地区：[1]宁夏回族自治区人民医院消化内科,银川750021

出　　处：《中国医师进修杂志（内科版）》2008年第1期5-7,共3页Chinese Journal of Postgraduates of Medicine

基　　金：宁夏回族自治区卫生厅重点科研计划项目（W200504）

摘　　要：目的利用荧光胃液分析与胃液中Hp相关性的研究，评估对胃癌癌前病变的诊断价值。方法收集980例各种胃内病变患者的胃液，用荧光胃液分析仪进行荧光胃液分析，同时进行胃液Hp检测。结果以受试者工作特征（ROC）曲线为最佳截断点KJF≥0．85作为胃癌判断标准，诊断胃癌的灵敏度为83．3％；重度萎缩性胃炎伴肠上皮化生及不典型增生患者的KJF值接近胃癌患者；在胃癌患者中胃液Hp检出率为45．2％，重度萎缩性胃炎伴肠上皮化生及不典型增生患者Hp检出率为69．3％。结论荧光胃液分析对胃癌的诊断是一种安全、有效的方法，对胃癌癌前病变的诊断特异度较高，且胃癌患者的胃液中Hp感染率较低。Objective To study the relationship between autofluorescence spectrum determination of gastric juice and Helicobacter pylori （Hp）, and evaluate the value of autofluorescence spectrum in diag- nosis of precancerous lesion of gastric cancer. Methods Gastric juice specimens of 980 patients with gastric diseases were collected from the patients underwent gastroscopy. Then the lluorescence spectrums were detected using lluorescence spectrophotometer and Hp of gastric juice was examined at the same time. Resuits The best critical point KJF ≥0.85 on receiver operating characteristic curve （ROC） was selected as diagnostic standard for gastric cancer. The sensitivity of gastric juice＇s autolluorescence spectrum for diagnosing gastric cancer was 83.3%. KJF of intestinal metaplasia and dysplasia of chronic gastritis was closed to that of gastric cancer. But the positive rate of gastric juice＇s Hp in gastric cancer was 45.2%. Hp positive rate in intestinal metaplasia and dysplasia of chronic gastritis was 69.3%. Conclusions Autolluorescence spectrum determination of gastric juice is a safe and effective method for clinical screening of early gastric cancer,but Hp positive rate in gastric cancer is decreased.

关 键 词：胃液 螺杆菌 幽门 胃癌 

分 类 号：R273.52[医药卫生—中西医结合]