芥子气对肾组织内皮素-1及内皮素A受体影响  

Effect of sulfur mustard on expression of endothelin-1 and endothelin A receptor in kidney

作　　者：曹霞[1] 张黎明[1] 

机构地区：[1]第二军医大学海医系防化医学教研室

出　　处：《中国公共卫生》2008年第1期36-38,共3页Chinese Journal of Public Health

基　　金：全军医药卫生“十五”指令课题资助项目(01L054)

摘　　要：目的探讨内皮素-1(ET-1)和内皮素A型受体(ETAR)在芥子气中毒病理生理过程中的作用。方法应用免疫组化及RT-PCR技术,观测大鼠芥子气中毒后肾组织ET-1、ETAR的转录表达变化及其与组织损伤的关系。结果中毒后肾组织ET-1的含量明显增加,6 h达峰值,24 h虽有所回落,但仍显著高于中毒前水平;中毒后肾组织ET-1及ETAR的mRNA表达均增加,ET-1 mRNA在24 h仍高于正常水平,ETAR mRNA在24 h恢复至正常组水平。结论ET-1及其受体ETAR在芥子气中毒后肾脏的病理生理过程中可能起重要作用。Objective To explore the role of endothelin-l（ET-1） and endothelin A receptor（ETAR） in pathophysiology of the kidney after sulfur mustard intoxication.Methods The changes of transcription and expression of ET-1 and ETAR in the kidney and their relationship with the tissue damage were studied in immunoassay histology and RT-PCR.Results The level of ET-1 in the kidney was significantly increased at 6 hours after intoxication.The transcription and expression of ET-1 and ETAR were significantly increased at the early stage after intoxication,mRNA of ET-1 was increased while mRNA of ETAR was down-regulated after 24 hours.Conclusion ET-1 and ETAR may play important roles in the pathophysiological process of the kidney after sulfur mustard intoxication.

关 键 词：芥子气 内皮素-1 内皮索受体A 肾脏 

分 类 号：R827.17[医药卫生—临床医学]