萘普待因的一般药理试验  

GENERAL PHARMACOLOGICAL EXPERIMENT OF NAPRODEINE

作　　者：林福生[1,2] 张守兰[1,2] 颜松民 陈久贞 林红 

机构地区：[1]北京药物化学研究所 [2]中国协和医科大学

出　　处：《中国药物依赖性通报》1997年第3期145-149,共5页

摘　　要：应用ＩＤＣ－１型多用生理电信号实时分析仪分别测定了萘普待因三种剂量（１４．９、２９．７、４４．６ｍｇ·ｋｇ－１，分别相当于人用剂量１、２、３倍）。ｉｇ给药１２０ｍｉｎ内药物对大鼠的心电、血压均无明显影响（Ｐ＞０．０５）。低剂量对大鼠的呼吸也无影响。中、高剂量给药３０ｍｉｎ后，大鼠的呼吸减慢加深，６０ｍｉｎ后基本恢复正常。观察各剂量组给药后的一般状况，未见异常。药物对小鼠自发活动的影响仅表现在高剂量组（８５．８ｍｇ·ｋｇ－１，相当于人用剂量的４倍），其小鼠自发活动次数及总强度与生理盐水（ＮＳ）组相比明显减弱（Ｐ＜０．０１），其余剂量组（２１．５、４２．９、６４．４ｍｇ·ｋｇ－１，分别相当于人用剂量的１、２、３倍）ｉｇ给药后，１２０ｍｉｎ内小鼠的自发活动无明显改变。The effects of three different doses of naprodeine (14.9, 29.7 and 44.6 mg·kg-1, 1, 2 and 3 times corresponding to clinical daily dose, respectively) on rat electrocardiogram, blood pressure and respiration were measured via “IDC-1 system of real-time analysis for physical electro-singals of animals'. The results indicated that three doses of naprodeine (ig) had no significant effect on electrocardiogram and systolic pressure in rat during 30 minutes-120 minutes after administration (P>0.05). Low dose had no influence on respiration in rat. When the rat received the doses of naprodeine, 29.7 mg·kg-1 and 44.6 mg·kg-1 the tidal volume of animal increased, and 60 minutes later, respiration returned to normal range. However, no abnomal changes were observed in each dose group after administration. Only the high dose (85.8 mg·kg-1,4 times corresponding to clinical daily dose) showed effect on mouse spontaneous movement. The number of mice spontaneous movement and total potency were significantly reduced compared with the group of NS (P<0.01). In the other doses (21.5, 42.9 and 64.4 mg·kg-1, 1, 2 and 3 times corresponding to clinical daily dose, respectively.), mouse spontaneous movement showed no significant change within 120 minutes after administration.

关 键 词：萘普待因 镇痛药 药理学 

分 类 号：R971.1[医药卫生—药品]