小儿肾脏疾病血、尿内皮素的变化  

The alternation of the level of plasmic and urinary endothelin in children with renal diseases

作　　者：魏仁桂[1] 陈述枚[1] 徐钟源[1] 

机构地区：[1]中山医科大学附属一院儿科

出　　处：《中华肾脏病杂志》1997年第4期218-220,共3页Chinese Journal of Nephrology

摘　　要：目的研究小儿肾脏疾病血、尿内皮素（ＰＥＴ、ＵＥＴ）的水平及其相互关系。方法采用同位素放免方法检测了肾病综合征（ＮＳ），肾小球肾炎（ＧＮ），肾功能衰竭（ＲＦ）共７２例患儿血及尿中ＥＴ，血心钠素（ＡＮＰ）水平。结果ＮＳ，ＧＮ，ＲＦ三组的ＰＥＴ及ＵＥＴ值明显高于对照组，尤其ＲＦ组（Ｐ＜００５，Ｐ＜０．０１）。ＡＮＰ值在ＧＮ组和ＲＦ组明显高于对照组（Ｐ＜００１）。８例ＡＲＦ患儿恢复期血ＥＴ水平下降，６例ＣＲＦ患儿虽经治疗，但血ＥＴ水平不降或上升。结论ＥＴ在小儿肾脏疾病发病机理及病情进展中可能起重要作用，其值高低与病情严重程度及预后有关。Objective To investigate the change of plasmic and urinary endothelin (PET,UET) level in children with renal disease and evaluate their relation. Methods The levels of PET, UET and ANP in 72 children with nephrotic syndrome (NS), glomerulonephritis(GN) and renal failure (RF) were measured using radioimmunoassay method. The relations between PET, UET, ANP and above renal disease were also investigated. Results The levels of PET and UET in NS, GN and RF groups were significantly higher than control group, especially in RF (P<0 05, P<0 01). The level of ANP in GN and RF group was also remarkably higher than control group (P<0 01). The level of PET decreased during recovery in 8 ARF cases, however, it did not decrease or increase in 6 CRF cases. Conclusion The ET possibly plays an important role in pathogenesis of these renal disease and its level change may be related to the progress and prognosis of these renal disease.

关 键 词：内皮素 肾病综合征 肾小球肾炎 肾功能衰竭 

分 类 号：R726.92[医药卫生—儿科] R362[医药卫生—临床医学]