人博卡病毒母婴感染的临床前瞻性研究  

Clinical prospective study on maternal-fetal transmission of human bocavirus

作　　者：郑敏巧[1] 林峰[1] 郑美云[1] 陈弘[1] 曾爱平[1] 吴峰[1] 

机构地区：[1]温州医学院附属温岭医院,浙江317500

出　　处：《中华实验和临床病毒学杂志》2007年第4期331-333,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的调查本地区人博卡病毒母婴感染情况。方法用ELISA检测母婴血清人博卡病毒IgG抗体及用荧光定量PCR检测母婴血清人博卡病毒DNA。结果316例母婴配对标本中,孕妇血清人博卡病毒IgG抗体阳性的有127例,阳性率为40.20%(127/316);新生儿脐带血人博卡病毒IgG抗体阳性有93例,阳性率为29.43%(93/316)。新生儿人博卡病毒IgG抗体阳性占母亲人博卡病毒IgG抗体阳性的百分比为73.23%(93/127)。母婴同时人博卡病毒IgG抗体阳性为93例。316例母婴配对标本人博卡病毒DNA均为阴性。结论人博卡病毒IgG抗体可从孕妇经胎盘传给新生儿,但是否存在人博卡病毒母婴垂直传播尚有待于进一步研究。Objective To investigate maternal-fetal IgG antibody to HBoV in serum samples of 316 mothers transmission at human bocavirns （HBoV）. Methods were determined with ELISA and HBoV DNA was determined with real time PCR in the sera of the mothers and their infants, Results HBoV-IgG was positive in 40,20% （127/316） of the mothers, while it was positive in 29.43% （93/316） of the cord blood specimens of the infants, The difference between the two groups was significant （ x^2 = 8,12, P 〈 0.005） ; 93 samples of both the mothers and the infants were positive for HBoV-IgG, Conclusions HBoV-IgG can cross the placenta to the fetuses through placenta, Furhter study is needed to answer the question whether vertical maternal-fetal transmission occurs.

关 键 词：细小病毒属 疾病传播 垂直 抗体 病毒 

分 类 号：R512.99[医药卫生—内科学] R714.2[医药卫生—临床医学]