抗肝纤冲剂治疗慢性乙型肝炎肝纤维化前后临床及病理研究  

Effects of Kang Gang Qian Granule (KGQG) on clinical and pathological features in chronic hepatitis B patients

作　　者：肖和杰[1] 石次国[1] 张爱萍[1] 李平[1] 范中善[2] 

机构地区：[1]三峡大学第三临床学院葛洲坝中心医院感染科,宜昌443002 [2]第二军医大学微生物教研室

出　　处：《中华实验和临床病毒学杂志》2007年第4期369-371,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的观察抗肝纤冲剂治疗慢性乙型肝炎肝纤维化的临床疗效,探讨其可能的作用机制。方法随机将57例慢性乙型肝炎肝纤维化患者分为两组。治疗组45例采用抗肝纤冲剂配合常规护肝药物治疗;对照组12例仅用常规护肝药物治疗。观察两组患者治疗前后血清肝功能、肝纤维化指标,并观察治疗前后肝组织病理及肝内Ⅳ型胶原免疫组化的改变。结果治疗组患者肝功能、肝纤维化指标、肝组织病理及肝内IV型胶原恢复程度均好于对照组(P<0.05或P<0.01)。结论抗肝纤冲剂配合常规护肝药物治疗慢性乙型肝炎肝纤维化患者疗效显著,为临床治疗慢性肝炎肝纤维化开辟了新的治疗途径。Objective To explore the efficacy of KGQG and its therapeutic mechanisms in chronic hepatitis B patients with liver fibrosis. Methods 57 chronic hepatitis B patients with liver fibrosis were randomly divided into two groups： 45 cases in KGQG group were treated by KGQG and routine medications; 12 cases in Control group were treated by routine medications only. Serum liver function test results, PCIII, CIV, HA and liver biopsy results of these 57 patients were simultaneously collected and analyzed before and after this intervention. Results KGQG group showed better efficacy over control group in liver function recovery, decrease of serum PC Ill , C IV , HA levels and liver pathologic grades （ P 〈 0,05 or 〈 O, O1 ）. Conclusion The KGQG could effectively ameliorate liver function and facilitate the inhibition and degradation of liver fibrosis in chronic hepatitis B patients, which may be developed as a novel therapeusis to treat this hard-to-cure disease.

关 键 词：抗肝纤冲剂 肝炎 乙型 慢性 肝硬化 肝/病理学 

分 类 号：R259[医药卫生—中西医结合]