延胡索乙素和延胡索炮制品提取物的药动学比较  

Comparison of Pharmacokinetics of Tetrahydropalmatine Monomer and Extractive of Corydalis and Corydalis Processed with Vinegar

作　　者：窦志英[1] 孙巍[1] 米晓兰[1] 姚丽萍[1] 

机构地区：[1]天津中医药大学,天津300193

出　　处：《中药材》2007年第12期1499-1501,共3页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金项目(30672664);天津市高等学校科技发展基金项目(2004309)

摘　　要：目的:研究延胡索乙素、延胡索生品和醋炙品提取物在大鼠体内的药动学。方法:高效液相色谱法测定血浆中延胡索乙素的血药浓度,采用3p97药动学处理软件,计算药动学参数,CmaxTmax采用实测值。结果:延胡索乙素单体、延胡索药材生品和醋炙品T1/2为(5.66±1.92)、(4.24±1.54)、(4.35±1.34)h;Tmax为(1.5±0.5)、(1.0±0.55)、(0.5±0.68)h;Cmax为(0.71±0.29)、(0.37±0.11)、(0.67±0.35)μg/ml;AUCo-t为(2.58±0.85)、(1.96±0.69)、(2.95±1.61)μg/ml。结论:延胡索生品和醋炙品均能缩短延胡索乙素的达峰时间,说明其两者能起效迅速。Objective ： To investigate the pharmacokinetics of tetrahydropalmatine monomer and extractive of corydalis and corydalis processed with vinegar in rats. Methods ： The plasma concentrations of tetrahydropalmatine were determined by a reversed phase high performance liquid chromatographic. The plasma concentrations-time data were calculated with 3p97 program. Results ： The main pharmacokinetic parameters of tetrahydropalmatine monomer and extractive of corydalis and corydalis processesd with vinegar as follows ：T1/2 was （5.66±1.92）,（4.24±1.54）,（4.35 ± 1.34） h,Tmax was （1.5 ±0.5）,（1.0 ±0.55）,（0.5 ±0.68） h,Cmax,was （0.71±0. 29）, （0. 37±0. 11 ）, （0.67 ±0. 35 ） μg/ml,AUC0-1, was （2. 58 ±0. 85 ）, （ 1.96 ± 0. 69）, （2.95 ± 1.61 ） μg/mL Conclusion： The T1/2 of corydalis and corydalis processesd with vinegar is more shorter than tetrahydropalmatine monome, the effect of preventing pain is promoted in rats.

关 键 词：延胡索 延胡索炮制品 延胡索乙素 药动学 

分 类 号：R283[医药卫生—中药学] R285[医药卫生—中医学]