挤出滚圆法制备大川芎方速释微丸的处方工艺研究  

Study on the Formulation and Process of Da Chuan Xiong Fang Pellet by Extrusion-spheronization

作　　者：洪燕龙[1] 冯怡[2] 徐德生[1] 姜玲海[2] 杨胤[2] 

机构地区：[1]上海中医药大学附属曙光医院,上海200021 [2]上海中医药大学中药学院,上海201203

出　　处：《中药材》2007年第12期1596-1600,共5页Journal of Chinese Medicinal Materials

基　　金：上海市重点学科建设项目资助项目(T0301)

摘　　要：目的:应用挤出滚圆法制备大川芎方微丸,研究中药微丸制备的新工艺。方法:在考察效应组分物理性质的基础上,用新型的挤出滚圆造粒机分别制备川芎、天麻速释微丸,采用单因素实验优化制剂处方及工艺条件,评价了微丸的粉体学性质、收率和体外溶出度。结果:用挤出滚圆法制备的川芎、天麻微丸在30 min内体外溶出均达90%以上,且圆整度好,粒度分布窄,收率高。结论:用国产的挤出滚圆造粒机可以制备中药微丸,该工艺简便易行,制得的速释微丸质量好,收率高,体外释药迅速。Objective： To study on the formulation and process of Da Chuan Xiong Fang pellet By extrusion-spheronization. Methods ： Based on the physical characters of active parts, the fast-release pellets of Chuan Xiong and Tian Ma were prepared separately By extrusion-spheronization. The formulation and process were studied By direct comparison. Then their characters were evaluated. Results ： The active components could release more than 90% in 30 minutes and the pellets presented perfect sphericity and narrow diameter distribution. Conclusion ： Pellets of TCM can Be prepared By homemade extrusion-spheronization machine and the fast-release pellets show perfect sphericity and narrow diameter distribution.

关 键 词：大川芎方 挤出滚圆法 速释微丸 川芎 天麻 

分 类 号：R284.2[医药卫生—中药学]