薄膜包衣工艺制备苦参总碱控释微丸的研究  

Preparation of Total Matrine Controlled Release Micropellet Capsules

作　　者：时军[1] 程怡[1] 李学涛[1] 

机构地区：[1]广州中医药大学中药学院,广东广州510045

出　　处：《中药材》2007年第12期1601-1603,共3页Journal of Chinese Medicinal Materials

摘　　要：目的:薄膜包衣工艺制备苦参总碱控释微丸。方法:采用GPCG-1型流化床包衣设备和乙基纤维素水分散体对苦参总碱液投入包衣,进行药物体外释放度研究和外观考察。结果:包衣微丸外观光洁,成膜均匀,体外释放符合零级动力学方程。结论:薄膜包衣工艺制备苦参总碱控释微丸方法可行,控释效果良好。Objective： To prepare total matrine controlled release micropellet capsules. Methods： The capsules were prepared by the technology of film-coating with surelease as matrix, and judged by the release behavior. Results ： The drug had completely been coated into a homogeneous and continuous film, and the results repeated in three batches showed that the release behavior of the pellet capsules followed zero-equation. Conclusion： The capsules have good sustained release effect and the process of the preparation is available.

关 键 词：薄膜包衣工艺 苦参总碱 控释微丸 

分 类 号：R284.2[医药卫生—中药学]