川芎嗪注射液治疗脑梗死72例的疗效观察  

Effect of Tetramethylpyrazine on 72 Cases of Cerebral Infarction

作　　者：曹观新[1] 卢伟[2] 胡祁生[1] 

机构地区：[1]武汉大学医学院生理系,湖北武汉430074 [2]中南大学湘雅二医院神经内科,湖北武汉430071

出　　处：《湖北民族学院学报（医学版）》2007年第4期19-21,共3页Journal of Hubei Minzu University(Medical Edition)

摘　　要：目的观察川芎嗪(TMP)注射液对脑梗死(CI)的治疗效果。方法将136例患者随机分为治疗组72例和对照组64例,治疗组给予常规治疗加盐酸川芎嗪注射液,对照组给予常规治疗,全部患者于治疗14 d后评估临床疗效,同时于治疗前和治疗14 d后测定血液流变学的各项指标(全血高切粘度、低切粘度、血浆粘度、红细胞压积、纤维蛋白原),于治疗前、治疗后1 d、2 d、7 d抽血查血液中肿瘤坏死因子(TNF-α)水平变化。结果治疗组总有效率89.9%,明显优于对照组的75%(P<0.05);在血液流变学改变上,治疗组治疗后各项指标均明显下降,与治疗前比较差异有显著性意义(P<0.05);对照组治疗后除血浆粘度和纤维蛋白原比治疗前有显著差异外(P<0.05),其它各项指标无明显变化(P>0.05).治疗组治疗后第1天、第2天血TNF-α水平较常规治疗组有明显降低(P<0.01)。结论川芎嗪注射液是一种安全有效的治疗脑梗死的脑保护剂,值得推广.Objective To investigate the effects of tetramethylpyrazine （TMP） on cerebral infarction. Methods 136 patients were randomly divided into the tetramethylpyrazine -treat group （72 patients） and the control group（64 patients）. Clinical outcomes were taken in all patients 14 days after treatment. Hemorheological indices were taken before treatment and 14 days after treatment. Tumor necrosis factor alpha（TNF - α） levels were checked in 1,2,and 7 days after treatment. Results The total effective rate in the tetramethylpyrazine - treat group was 89.9%, much higher than 75% of the control group（P 〈0.05）. There was significant difference in all the hemorheological indices before and after treatment in treated group（P 〈0.05）. In the control group, no other index except serum viscosity and fibrinogen was different between before and after treatment. TNF - α level was much lower in the first and second days in the tet- ramethylpyrazine - treat group than the control group （P 〈 0. 01 ）. Conclusion Tetrameth- ylpyrazine is a brain protective agent,which is very safe and effective and can be popularized.

关 键 词：川芎嗪/治疗应用 脑梗死 

分 类 号：R285.6[医药卫生—中药学]