优甲乐和稳定性碘干预^131I致大鼠甲状腺功能减低的研究  

Interventions of euthyrox and stable iodine in hypothyroid occurrence of rats treated with ^131I

作　　者：李诗运[1] 谭本旭[1] 戴儒奇[1] 姚爱珠[1] 白殿卿[2] 韩景辉[3] 

机构地区：[1]海南省人民医院核医学科,海口570311 [2]海南省实验动物中心,海口570311 [3]海南省人民医院检验科,海口570311

出　　处：《国际放射医学核医学杂志》2007年第6期325-328,共4页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：海南省卫生厅基金项目（200275）

摘　　要：目的探讨优甲乐和稳定性碘对^131I处理实验鼠后致甲减的影响，为临床^131I治疗甲亢和非毒性甲状腺肿提供参考。方法54只Wistar大鼠平均分成三组，三组均按甲状腺质量计算^131I给予剂量，A组单纯给予^131I作为对照组；B组于^131I处理后第20日起连续给予优甲乐片，共计30d；C组在^131I处理后24h给予稳定性碘10μmol。三组给mtI后15，60，90d测定血清三碘甲腺原氨酸（T3）、甲状腺素（T4）及促甲状腺激素（TSH）水平，并取甲状腺组织切片计数每高倍镜视野下甲状腺细胞数。结果^131I处理后15d，三组甲状腺细胞计数及各项功能观察指标均无统计学差异。随着时间推移。三组之间出现统计学差异：60d时C组T4低于B组（q=5．16，P〈0．05）；90d时C组游离T4、总T4低于A、B两组（q值分别为3．31和7．69，P〈0．05）。结论^131I处理后早期对大鼠给予优甲乐片十预能有效改善甲状腺滤泡的受损情况，从而降低甲减的发生；大鼠^131I处理后24h给予稳定性碘干预则加重^131I对甲状腺的损伤。Objective To investigate the effects of stable iodine and thyroxin on the hypothyroid occurrence of rats treated with ^131I thus to provide reference in clinical ^131I therapy for hyperthyroid and nontoxic goiter. Methods 54 Wistar rats are equally divided into three groups, whose ^131I dose can be calculated by their mass. Group A accept only ^131I as contrast, group B accept Euthyrox （200 pg/d, 30d） after ^131I treatment, group C accept 10μmol stable iodine 24 h after ^131I theatment. Serum triiodothyronine （T3）, thyroxine （T4）, thyroid-stimulating hormone （TSH） are measured and cell numbers per high power lens（4×100）are counted in 15, 60, 90 d following ^131I treatment respectively. All the data are analysed by Fisher test and q test. Results 15 d posttreatment, neither cell numbers nor serum T3, T4 and TSH among three groups has statistically variance. With time prolonging, serum T3 , T4 of group C decreased quicker than the other two groups （in 60 d, T4 of group C is less than group B, q=5.16, P〈0.05; in 90 d, T4 of group C is less than group A and B, q value is 3.31 and 7.69 respectively, P〈0.05）. Conclusions Giving the rats euthyrox in time post ^131I treatment can not only alleviate the damage in thyroid cells from β-rays, but also decrease the incidence of hypothyroid. On the other hand, giving the rats stable iodine simultaneously probably can prolong the effective half-life of ^131I , thus aggravate the damages and increase the incidence of hypothyroid.

关 键 词：甲状腺功能减退症 碘放射性同位素 甲状腺素 稳定性碘 药物疗法 

分 类 号：R5[医药卫生—内科学]