OPCABG术后阿司匹林抵抗的观察  

Aspirin resistance after off-pump coronary artery bypass surgery

作　　者：宋心雨[1] 邹承伟[2] 李红昕[2] 

机构地区：[1]苏州大学附属第一医院,江苏苏州215006 [2]山东省立医院

出　　处：《山东医药》2007年第36期22-23,共2页Shandong Medical Journal

摘　　要：目的探讨非体外循环冠状动脉搭桥术(OPCABG)后阿司匹林抵抗(AR)规律。方法应用流式细胞技术,检测56例OPCABG患者血小板膜表面活化标记物CD62P及PAC-1的表达情况。结果术前口服阿司匹林后CD62P、PAC-1阳性表达率分别为6.04%±5.80%、13.63%±12.70%;术后1 d分别为10.20%±3.40%、15.45%±9.40%,均明显降低(P<0.05);术后5 d分别为21.02%±16.52%、39.24%±11.53%,与术后1 d相比均明显升高(P<0.05);术后10 d分别为5.65%±1.12%、16.01%±5.43%,与术前口服阿司匹林后相比,P>0.05。结论OPCABG后存在一过性AR。[ Objective ] To investigate whether patients who underdone off-pump coronary artery bypass grafting develop aspirin resistance after surgery. [ Methods] The positive rates of CD62P and PAC-1 on platelets as the molecular markers of CAP were analyzed by flow cytometric 3-color immunofluorescence. [ Results] 5 days after surgery, aspirin treatment did not result in a significant inhibition of platelet function. Ten day after surgery, the positive rates of CD62P and PAC-1 were both reduced to the level before surgery. [ Conclusion] Patients who showed a normal sensitivity to aspirin before OPCABG develop aspirin resistance after surgery, but this phenomenon is time-dependent.

关 键 词：冠状动脉搭桥术 阿司匹林抵抗 血小板 

分 类 号：R654.2[医药卫生—外科学]