α7-烟碱样乙酰胆碱受体基因rs1042724多态性与精神分裂症的关联研究  

The study of genetic association between schizophrenia and rs1042724 polymorphism at nucleotide of the nicotine-like acetylcholinergic receptor gene

作　　者：郭娟[1] 于海龙[2] 陈元堂[1] 

机构地区：[1]陕西省西安市精神卫生中心,西安710061 [2]江苏省宿迁市公安局刑警支队

出　　处：《精神医学杂志》2007年第4期195-197,共3页Journal of Psychiatry

基　　金：陕西省卫生厅基金课题;编号:06034

摘　　要：目的研究α7-烟碱样乙酰胆碱受体基因rs1042724多态性与精神分裂症的相关性。方法运用聚合酶链反应扩增及单核苷酸多态性的分子生物学技术,对符合精神分裂症诊断标准的98个先证者及其父母组成的核心家系,测定α7-烟碱样乙酰胆碱受体基因分型,进行精神分裂症的α7-烟碱样乙酰胆碱受体基因多态性的关联分析和传递不平衡(TDT)检验。结果TDT检验结果提示α7-烟碱样乙酰胆碱受体基因等位基因与精神分裂症之间的相关性(McNemarχ2=4.21,P<0.05),且等位基因T携带者,其精神分裂症的易患性是C携带者的1.31倍(RR=1.31,χ2(RR)=3.96,P<0.05)。结论提示α7-烟碱样乙酰胆碱受体基因rs1042724与精神分裂症相关联。Objective To detect the genetic association between schizophrenia and rs1042724 polymorphism at nucleotide of the nicotine-like acetylcholinergic receptor gene. Methods Observed in a sample of 98 parent/ offspring trios where the proband met the criteria of DSM-Ⅳ for schizophrenia using transmission/disequilibrium test （TDT） analysis. The polymorphism of nicotine-like acetylcholinergic receptor gene was detected with PCR methods and SNP typing in all nucleus families. Results Using a family-based association design,we obtained evidence of an association between schizophrenia and allele of the rs1042724 polymorphism in the nicotine-like acetylcholinergic receptor gene （RR = 1. 31, χ^2 （RR） = 3. 96, P 〈 0. 05） . Moreover, the fact that transmission disequilibrium was observed when one affected offspring was selected atrandom from each family, suggesting that the results were due to association（McNemar χ^2= 4.21,P〈0.05）. Conclusion It shows an association between schizophrenia and the rs1042724 polymorphism at nucleotide of the nicotine-like acetylcholinergic receptor gene.

关 键 词：精神分裂症 α7-烟碱样乙酰胆碱受体 多态性 关联分析 

分 类 号：R681.02[医药卫生—骨科学]