147株铜绿假单胞菌的分布及耐药性分析  

Distribution and its antibiotic resistance in 147 strains of Pseudomonas aerugirosa

作　　者：汪宏梅[1] 

机构地区：[1]江苏省泰兴市人民医院,225400

出　　处：《检验医学与临床》2008年第2期68-69,71,共3页Laboratory Medicine and Clinic

摘　　要：目的了解铜绿假单胞菌的分布及对抗生素的耐药情况,为临床提供直接可靠的参考依据。方法抽取147例院内感染铜绿假单胞菌病例,分别对临床感染状况分布、细菌耐药性、抗菌药物使用情况进行回顾性分析。结果铜绿假单胞菌从痰标本中分离的菌株最多,阳性率为51.0%;对铜绿假单胞菌敏感性最高的是头孢哌酮/舒巴坦(占86.3%),其次是亚胺培南(81.0%)、环丙沙星(78.8%);耐药性最高的是复方新诺明(占98.0%),其次是氯霉素(84.3%)、头孢噻肟(71.0%)。结论医院感染铜绿假单胞菌的情况十分严峻,建立健全院内感染测试系统,加强细菌和药敏监测,及时从经验治疗改为针对各菌种治疗,选择敏感性强的药物,避免广谱抗菌药物的长期应用,才能减少抗菌药物的选择压力。Objective To investigate the distribution of Pseudomonas aeruginosa（P, aeruginosa） and its antibiotic resistance profiles for providing the reliable reference for clinical practice. Methods The data were collected from the patients infected by P. aeruginosa in hospital. The clinical distribution status of infection, the antibiotic resistance and the usage of antibiotics were retrospectively analyzed respectively. Results P. aeruginosa isolates separated from sputum specimens were predominant, with the positive rate of 5.1%. The susceptibility rate of P. aeruginosa to Cefoperazone was the highest（86.3 %）, while to imipenem and ciprofloxacin were 81.0%, 78.8% respectively. The highest resistant rate to sulfamethoxazole was 98.0 M. The following two were chloramphenicol and cefotaxime, with resistant rates of 84.3 % and 71% respectively. Conclusion It is greatly recommended to construct an infection test system and strengthen the supervision of bacterium and the medicine sensitivity in hospital, since the status of P. aeruginosa infection in hospital is extremely severe. In order to reduce the stress of selecting antibiotics, it is necessary to immediately use the specific treatment based on different bacteria in stead of the conventional treatment, choose a high-sensitive medicine and avoid the long-term administration of the broad spectrum antibiotics.

关 键 词：铜绿假单胞菌 交叉感染 药物耐受性 

分 类 号：R378.991[医药卫生—病原生物学] R969.4[医药卫生—基础医学]