酸敏感离子通道的特性及其调控  

Characteristics and Regulation of Acid-sensing Ion Channels

作　　者：宋娜娜[1] 沈霖霖[1] 

机构地区：[1]复旦大学上海医学院生理与病理生理学系,上海200032

出　　处：《医学综述》2008年第2期161-164,共4页Medical Recapitulate

基　　金：国家自然科学基金项目(30670771)

摘　　要：酸敏感离子通道(ASICs)是一类由胞外酸化所激活的阳离子通道,在中枢和外周广泛分布。已经克隆出由4个基因编码ASICs的6个亚单位,ASICs的拓扑结构也得到证实。ASICs的功能与组织酸化引起的痛觉和触觉等有关,近年来认为ASICs可能在中枢发挥重要作用,具有中枢神经突触传递调节等方面的作用。目前,对ASICs亚基调控的研究有了很大的进展,尤其是发现了几种特异性的ASICs阻断剂后,为ASICs的研究提供有效的工具药。文章主要介绍ASICs的特性及在调控方面的研究进展。The acid-sensing ion channels （ASICs） are the cation channels activated by extraeellular acidosis. They have wide distribution in central and periphery nervous system. Six subunits of ASIC encoded by four genes have been cloned and their topological organization has been eoufinned. Their functions are related to feeling of pain and touch resulting from tissue acidosis. Recent years, Asies might play an important role in central system, having the effect in regulating the synaptie transmission of central nerve. The studies about regulation of subunit of ASICs had achieved great progresses, especially the finding of several specific ASICs blocker hod provide effective tool for the study of ASICs. This article reviews ASICs about its feature and some progresses on regulation.

关 键 词：酸敏感离子通道 电生理学 调控 

分 类 号：Q424[生物学—神经生物学]