补体片段C_4d病理学研究进展  

Pathological Study Progress of C_4d

作　　者：丁鑫[1] 郑智勇[2] 余英豪[2] 

机构地区：[1]福建医科大学福总临床医学院,福州350025 [2]中国人民解放军南京军区福州总医院病理科,福州350025

出　　处：《医学综述》2008年第2期188-190,共3页Medical Recapitulate

摘　　要：补体片段C4d是补体成分C4裂解产物,主要参与补体经典途径的激活。在体液免疫反应中,C4d可以借共价键与血管内皮或基底膜结合并长期存在。因此C4d能够反应体液免疫反应的存在,尤其是在器官移植中反映排斥反应的存在。近年来C4d在病理学中应用研究方面又有了一些重要发现,如在自身免疫性疾病、淋巴瘤、妊娠性肾病诊断方面的应用。Complement C4d is a split product of complement C4, and mainly participate the activation of classical pathway of complement. In humoral immune reaction, C4 d can combine with blood vessel endothelium or basement membrane hy covalent hind, which can exist in long-feral. CAd can reflect the existence of humoral immune reactinn, especially the existence of reject reaction in organ transplantation. Recent years, there are other important findings of C4d about its application study in pathology, for example the application in the diagnosis of autoimmune diseases, lymphoma and gestational nephrosis.

关 键 词：补体 C4D 病理学 器官移植 移植物排斥 

分 类 号：R392.11[医药卫生—免疫学]