长时程突触可塑性中的突触标识  

Synaptic Tagging in Process of Long-Term Synaptic Plasticity

作　　者：毛慕华[1] 刘宗生[1] 胡江元[2] 

机构地区：[1]井冈山大学医学院,江西吉安343000 [2]哥伦比亚大学神经生物学与行为中心,纽约10032

出　　处：《生理科学进展》2008年第1期21-26,共6页Progress in Physiological Sciences

摘　　要：神经元长时程突触可塑性是学习和记忆的基础,神经元长时程突触可塑性的维持依赖于基因的转录和蛋白质合成。然而,这些转录产物和新合成的蛋白质是如何从胞体运输到突触点,还不甚清楚。近年来的研究显示,当长时程突触可塑性发生时,被激活的突触能通过建立突触标记(synaptic tag)来识别、捕捉和利用其所需要的基因产物,以维持突触可塑性的长时程变化。这一过程或现象被称为突触标识(synaptic tagging)。本文就近年来突触标识的研究进展作一概述。Long-term synaptic plasticity is the cellular and molecular basis of learning and memory, and the maintenance of their late phases requires both transcription and translation. How targeting gene products shipped from cell body to the few activated synapses in a vast dendritic tree is not yet fully understood. The recent researches demonstrated that the induction of long-term synaptic plasticity could mark an activated synapse by a synaptic tag to capture and utilize synaptic plasticity-related transcriptional products that then serve to stabilize early to late phase of long-term synaptic plasticity. In this review, we outline the advancement in research of synaptic tagging.

关 键 词：突触可塑性 突触标识 长时程增强 长时程抑制 

分 类 号：R338.1[医药卫生—人体生理学]