类风湿性关节炎危险因素病例对照研究  

A CASE-CONTROL STUDY ON THE RISK FACTORS OF RHEUMATOID ARTHRITIS

作　　者：朱湘竹[1] 蓝绍颖[1] 朱建平 王苏容[3] 

机构地区：[1]南通大学公共卫生学院流行病学教研室,南通226001 [2]南通良春中医药研究所 [3]南通大学护理学院

出　　处：《现代预防医学》2008年第2期213-215,共3页Modern Preventive Medicine

基　　金：南通市科技计划项目(S40013);南通医学院中青年基金(03101224)

摘　　要：[目的]探索类风湿性关节炎(RA)的危险因素。[方法]105例确诊的类风湿性关节炎患者为病例组,按性别、年龄匹配,每个病例选择2名健康人与之匹配。采用统一问卷进行调查。[结果]有统计学意义的因素有:文化水平(OR=0.62,95%CI:0.43～0.89)、家庭经济状况(OR=0.62,95%CI:0.40～0.98)、潮湿(OR=3.70,95%CI:1.98～6.91)、扁桃体经常发炎(OR=4.88,95%CI:1.96～12.14)、被动吸烟(OR=2.71,95%CI:1.50～4.87)。女性因素中月经初龄(OR=2.32,95%CI:1.07～5.02)。[结论]社会经济状况较低的人群更容易患类风湿性关节炎,环境潮湿、经常扁桃体发炎、被动吸烟与类风湿性关节炎发生有关。在女性因素中,月经初龄与女性类风湿性关节炎有关。[ Objective ] To investigate the risk of rheumatoid arthritis （IRA）. [ Methods ] By 1 ： 2 matched case-control study paired by sex and age, 105 patients with RA were recruited as cases and 210 health citizens were recruited as controls to investigate with unified questionnaires. [ Results] Five factors showed significantly associated with RA： education background （OR =0.62, 95%CI： 0.43-0.89）, family economic status （OR =0.62, 95%CI： 0.40-0.98）. humidity （OR = 3.70, 95% CI： 1.98-6.91）, regularity tonsillitis （OR = 4.88. 95%CI： 1.96-12.14）. passive smoking （OR = 2.71, 95%CI： 1.50- 4.87）, the age of menarehe （OR = 0.34. 95%CI： 0.17- 0.69）. [Conclusion] People with poor economic status are earlier suffered from RA, and tile humidity, regularity tonsillitis and passive smoking are significantly associated with RA. For women, the age of menarehe is significantly associated with RA.

关 键 词：类风湿性关节炎 危险因素 1:2病例对照研究 条件LOGISTIC回归 

分 类 号：R593.22[医药卫生—内科学]