NAD（P）H氧化酶p22phox亚基C242T基因多态与颈动脉粥样硬化  

Correlation between NAD （P）H oxidase p22phox C242T polymorphism and carotid atherosclerosis

作　　者：张晨[1] 宋玉强[1] 张晓兰[1] 

机构地区：[1]青岛大学医学院附属医院神经内科,266003

出　　处：《中华神经科杂志》2008年第1期25-28,共4页Chinese Journal of Neurology

摘　　要：目的探讨在中国青岛地区汉族人群中NAD（P）H氧化酶p22phox亚基C242T基因多态与颈动脉粥样硬化（CA）的相关性。方法共收集138例CA患者和130名对照者，用聚合酶链反应-限制性片段长度多态分析（PCR-RFLP）方法确定其基因型，计数资料比较应用卡方检验。结果CA组和对照组的CT基因型频率分别为0．268和0．139，两组差异具有统计学意义（χ^2=6．899，P=0．009），未发现有TT基因型。CA组的T等位基因频率亦高于对照组（χ^2=6．110，P=0．013）。多元逐步Logistic回归分析显示收缩压、血糖、低密度脂蛋白胆固醇、吸烟以及CYBA基因C242T多态都是CA的独立危险因素。结论NAD（P）H氧化酶p22phox亚基C242T多态可能是CA的一个危险因素。Objective To investigate the correlation between NAD （P）H oxidase p22phox C242T polymorphism and carotid atherosclerosis （CA） in Chinese population. Methods 138 patients with CA and 130 control subjects were recruited. C242T polymorphism of p22phox was analyzed by polymerase chain reaction and restriction fragment length polymorphism （PCR-RFLP） for determination of its genotype. Results The CT genotype frequencies in the CA group and control group were 0. 268 and 0. 139, respectively, and no TF genotype was found. The CT genotype frequency of the CA group was significantly higher than that of the control group （χ^2 = 6. 899, P = 0. 009 ）. It was found that systolic blood pressure, blood glucose, low density lipoprotein cholesterol smoking and the NAD （P）H oxidase p22phox C242T polymorphism were independent risk factors for CA by Logistic regression analysis. Conclusions The NAD（P） H oxidase p22phox C242T polymorphism may be a risk factor for CA.

关 键 词：颈动脉疾病 NADPH氧化酶 多态性 限制性片段长度 

分 类 号：R686[医药卫生—骨科学]