依诺肝素钠的制备与纯化  

Preparation and Purification of Enoxaparin Sodium

作　　者：金飞[1] 徐飞虎[2] 王彦广[1] 

机构地区：[1]浙江大学化学系,浙江杭州310027 [2]杭州九源基因工程有限公司,浙江杭州310018

出　　处：《中国医药工业杂志》2008年第1期15-17,共3页Chinese Journal of Pharmaceuticals

摘　　要：以肝素钠为原料,经成盐、酯化、解聚和纯化得到依诺肝素钠。研究了影响酯化率与成环率的主要因素,控制合适的酯化、解聚和纯化条件,得到的依诺肝素钠成品符合欧洲药典标准。Enoxaparin sodium was prepared from heparin sodium via salinization, esterification, depolymerization and purification. Major factors that affected the degree of esterification and 1,6-anhydro ring formation were studied to produce the title compound which met the European Pharmacopoeia standard.

关 键 词：肝素钠 酯化 依诺肝素钠 大孔吸附树脂 

分 类 号：TQ460.31[化学工程—制药化工]