醋柳黄酮与其固体脂质纳米粒在小鼠血中浓度的比较  

Study on the difference between the concentration of TFH and TFH-SLN in mice plasma

作　　者：杨宏昕[1] 石文宏 盛惟 

机构地区：[1]内蒙古自治区医院,呼和浩特010017 [2]内蒙古药品检验所,呼和浩特010020

出　　处：《中国民族医药杂志》2007年第4期42-43,共2页Journal of Medicine and Pharmacy of Chinese Minorities

摘　　要：目的:研究醋柳黄酮在小鼠体内血药浓度的测定方法,比较醋柳黄酮胶囊和其口服固体脂质纳米粒在小鼠血液中的药物浓度。方法:采用HPLC法测定口服醋柳黄酮胶囊和其口服固体脂质纳米粒在小鼠血液中的药物浓度,采用3P87药动学程序求算药物动力学参数。结果:醋柳黄酮口服固体脂质纳米粒在小鼠血液中的药物浓度高于醋柳黄酮胶囊。结论:醋柳黄酮口服固体脂质纳米粒可显著提高药物的相对生物利用度。Objective： To study a method to determine the concentration of TFH in mice plasma, then to compare the concentration of TFHC to that of TFH - SLN. Methods： The concentration of TFHC and TFH - SLN were determined with HPLC.The parameters of pharmacokineticd were calculated with a software 3P87. Resuhs： The concentration in mice plasma was higher in TFH - SLN group than in TFHC group. Conclusions： TFH - SLN may enhance the absorp- tion of TFHC significantly, and TFH -SLN has plasma targeting clearly.

关 键 词：醋柳黄酮 固体脂质纳米粒 血药浓度 

分 类 号：R291.2[医药卫生—民族医学]