新生儿乙肝疫苗接种20年后人群的HBV血清流行病学特征研究  

Study on Sero-epidemiology of Hepatitis B in Population After Newborns Inoculating With Hepatitis B Vaccine for 20 Years

作　　者：王继杰[1] 颜天强[1] 陈子君[1] 文中兰[1] 肖正安[1] 张勇[2] 

机构地区：[1]湖南省湘潭市疾病预防控制中心,湖南湘潭411100 [2]中国疾病预防控制中心病毒病控制所

出　　处：《实用预防医学》2007年第6期1672-1674,共3页Practical Preventive Medicine

基　　金：国家"七五"攻关课题<乙肝流行因素;免疫策略及免疫效果研究>后续研究

摘　　要：目的了解现阶段人群乙型肝炎病毒(HBV)感染现状;评价自1985年4月开展新生儿接种乙肝疫苗免疫策略所取得的成果。方法在国家"七五"攻关课题试点区,应用整群抽样的方法,以家庭为单位,采取血清,应用固相放射免疫法(SPRIA)检测HBsAg、抗—HBs和抗—HBc。结果人群HBsAg阳性率、抗—HBs阳性率和HBV流行率经标化后分别为6.03%、37.75%和37.33%;HBsAg阳性率、HBV流行率均低于1987年同一地区的检测结果,尤以<20岁青少年降低比较明显;抗—HBs阳性率则高于1987年同一地区的检测结果,尤以<20岁青少年升高明显。结论人群乙肝流行病学特征已发生改变,新生儿乙肝疫苗接种已取得了很大的成绩。Objective To understand and measure the impact form immunization activities, and to evaluate the vaccination achievements of the large- scale newborn hepatitis B vaccine since April, 198,5. Methods We conducted sero--epidemiological studies in national ＂75＂ science and technology attack topic observation area, The group sampling method was applied, Each family served as the observation unit and each subject was gathered venous blood, HBsAg, anti - HBs and anti - HBc in their blood samples were tested by SPRIA. Results HBsAg positive rate, anti - HBs positive rate and HBV infection rate among populations were 6.03 %, 37. 75 % and 37.33 % respectively. The HBsAg positive rate and HBV infection rate were declined while the anti - HBs positive rate was raised significantly in the same areas as compared with the data of 1987, Conclusions The results suggest that the epidemiological characteristics of hepatitis B have already changed in China, The newborn hepatitis B vaccination program obtains a satisfactory result.

关 键 词：乙型肝炎 血清流行病学 乙肝疫苗 预防接种 

分 类 号：R186[医药卫生—流行病学]