雷米普利对慢性肾衰竭患者血压和肾功能的影响  

The Effect of Ramiprif on the Hypertension and Renal Function of patients with Chronic Renal Failure

作　　者：姜鸿[1] 程骏章[1] 雷清凤[1] 吴庆[1] 马特安[1] 刘晓[1] 朱晓华[1] 

机构地区：[1]长江大学附属第一医院荆州市第一人民医院肾内科,湖北荆州434000

出　　处：《长江大学学报（自科版）（下旬）》2007年第4期344-345,共2页Journal of Yangtze University

摘　　要：目的:探讨血管紧张素II转化酶抑制剂雷米普利(Ramiprif)对慢性肾功能衰竭(CRF)患者肾脏的保护作用。方法:将46例CRF患者随机分为治疗组(雷米普利2.5mg/d)与对照组(硝苯地平控释片30mg/d),2组均加用美托洛尔50mg,q12h,连用8周。检测治疗前后患者的血压、血肌酐和尿蛋白等。结果:2组在治疗后血压明显降低(P<0.01),但组间在血压达标情况上差异无显著性(P>0.05);2组患者血肌酐均显著下降(P<0.01),但组间差异亦无显著性(P>0.05);但雷米普利组24h尿蛋白定量减少幅度明显大于硝苯地平控释片组(P<0.01)。结论:雷米普利对CRF的肾脏病变具有保护作用,在降低蛋白尿的程度上明显强于硝苯地平控释片。Objective:To investigate the renal protective effect of Ramiprif on patients with chronic renal failure (CRF).Methods: 46 patients with CRF were randomly divided to receive once daily 2.5 mg Ramiprif plus twe daily Betaloc 50mg or once daily nifedipine 30mg plus twe daily Betaloc 50mg for 8weeks. Arterial pressure and the level of serum Creatinine and urine protein was detected before and after treatment.Results:there were significant reduction (P<0.01) in the blood pressure after therapy,but there was on difference in the two groups(P>0.05);there were significant reduction (P<0.01) in the blood Creatinine after therapy except between the two groups(P>0.05);In Ramiprif group, the excretion of urine protein was significantly lower than that of nifedipine group(P<0.01).Conclusions:The results obtained indicated that Ramiprif has renal protective effect on patients with CRF and it is better to reduce urine protein value than nifedipine.

关 键 词：慢性肾功能衰竭 雷米普利 高血压 蛋白尿 

分 类 号：R692.5[医药卫生—泌尿科学]