肉桂油固体分散体的制备及体外释放  

Preparation and in vitro dissolution of the solid dispersions of cinnamon oil

作　　者：姚琳[1] 邓康颖[1] 罗佳波[1] 

机构地区：[1]南方医科大学中医药学院,广东广州510515

出　　处：《南方医科大学学报》2008年第1期52-53,56,共3页Journal of Southern Medical University

基　　金：国家自然科学基金(300301500)~~

摘　　要：目的以硬脂酸、聚乙二醇6000和单硬脂酸甘油酯为辅料,制备肉桂油缓释胶囊。方法应用熔融法制备固体分散体后,以溶出度的测定为主要评价指标,采用正交设计对工艺及处方优化,并用红外光谱法考察药物与载体是否具有相互作用。结果所得优化处方体外释放符合Higuchi模型,体外可持续释药12h,红外光谱分析表明药物与辅料发生了相互作用,形成了固体分散体。结论通过以上处方和工艺制得的固体分散体胶囊具有明显缓释作用,工艺简单,重现性好。Objective To prepare sustained-release capsules of cinnamon oil with stearic acid, polyethylene glycol 6000 and gluceryl monostearate. Methods After the solid dispersion of cinnamon oil was prepared by melting method, the effects of the process variables and formulation variables on solid dispersion and dissolution were investigated. The formulation and preparation process of cinnamon oil solid dispersion were optimized by orthogonal design, and Fourier-transformed infrared （FTIR） spectroscopy was employed to detect the possible molecular interaction between cinnamon oil and the adjuvants. Results The in vitro release percentage of the optimized formula complied with the Higuchi equation, and the preparation allowed drug delivery for 12 h. Analysis with FTIR spectroscopy revealed interactions between cinnamon oil and the adjuvents and formation of the solid dispersion. Conclusion The solid dispersion capsules prepared through this simple and well reproducible process allow obviouly sustained release of cinnamon oil.

关 键 词：肉桂油 同体分散体 缓释胶囊 体外释放 正交设计 

分 类 号：R284.2[医药卫生—中药学]