桦木酸和2,3-羟基桦木酸抗肿瘤作用机制的研究进展  

Study Progress of Anti-tumor Mechanism of Betulinic Acid and 2,3-hydroxyl Betulinic Acid

作　　者：张晶[1] 张秀娟[1] 凌莉莉[1] 

机构地区：[1]哈尔滨商业大学生命科学与环境科学研究发展中心,黑龙江哈尔滨150076

出　　处：《亚太传统医药》2008年第1期62-64,共3页Asia-Pacific Traditional Medicine

基　　金：哈尔滨商业大学研究生创新基金项目;黑龙江省自然科学基金项目(C200604)

摘　　要：桦木酸和2,3-羟基桦木酸均是羽扇豆烷型五环三萜类化合物,具有多方面的药理活性,其抗肿瘤作用近年来受到了极大的关注。目前,国内外关于桦木酸和2,3-羟基桦木酸抗肿瘤作用的研究表明,桦木酸和2,3-羟基桦木酸可通过抑制肿瘤细胞增殖、转移,诱导肿瘤细胞分化和凋亡,从而起到抗肿瘤的作用。Betulinic acid and 2,3-hydroxyl betulinic acid were lupine-type tings Ttiterpenoid compounds, They had wide range of pharmacological activity, the anti-tumor effect has been of great concern in recent years. At presem betulinic acid and 2,3 -hydroxyl betulinic acid anti-tumor effect studies in home and abroad show that betulinic acid and 2,3-hydroxyl betulinic acid can inhibit tumor cell proliferation, transfer, induced differentiation and apoptosis of tumor cells, thus played the role of anti-tumor action.

关 键 词：桦木酸 2 3-羟基桦木酸 抗肿瘤 

分 类 号：R96[医药卫生—药理学]