肺炎衣原体与冠心病关系的研究  

Relationship between chlamydia pneumoniae and coronary atherosclerotic heart disease

作　　者：李文化[1] 张雪雨[1] 程铮[1] 李新军[1] 宋彦恩[1] 

机构地区：[1]河北北方学院第二附属医院内四病区,张家口075100

出　　处：《陕西医学杂志》2008年第1期62-64,共3页Shaanxi Medical Journal

基　　金：河北省科技厅指导项目(No 002761107)

摘　　要：目的:探讨肺炎衣原体(TWAR)与冠状动脉粥样硬化心脏病(CHD)之间的关系。方法:采用多聚合酶链反应(PCR)技术对200例冠心病和180例非冠心病患者进行全血标本肺炎衣原体DNA检测。结果:冠心病组肺炎衣原体DNA阳性率为57.5%,对照组为21.1%,两组有显著性差异(P<0.01);另外,在冠心病组,肺炎衣原体DNA阳性率:男性显著高于女性(P<0.01);吸烟患者显著高于非吸烟患者(P<0.01);急性心梗较其他类型冠心病相比有显著性差异(P<0.01)。结论:肺炎衣原体感染与冠心病存在密切关系,可能是冠心病发生、发展的因素之一。Objective： To investigate the relationship between chlamydia pneumoniae （TWAR） and coronary atherosclerotic heart dlsease（CHD） . Methods ： By means of polymerase chain reaction（PCR）, TWAR nucleic acid were detected in 200 patients with CHD and 180 control subjects. Results：The positlvity rate of TWAR-DNA was 57.5%（115/200） in the patient group and 21. 1%（38/180） in the control group, showing obvious difference between the two groups（P 〈0. 01）. In addition, the positivity rate of TWAR-DNA was 64. 8%, 71. 6%, 73.2% in male , smoking or AMI patients with CHD and 26.3%, 17.3%, 51.3% in the control patients with CHD, respectively, which shows significant difference （P〈0. 01, P 〈0. 01, P 〈0. 01）. Conclusion： TWAR infection is closely connected with CHD, and may be one of the risk factors in CHD mechanisms.

关 键 词：冠状动脉疾病/病因学 冠状动脉疾病/血液 衣原体 肺炎/血液 聚合酶链反应 

分 类 号：R560.4[医药卫生—呼吸系统] R541.4[医药卫生—内科学]