铬在大鼠急性肺损伤中变化及参脉的干预作用  

The infuluence of Shenmai effects on Chrome level to the rat when ALI

作　　者：曹慧玲[1] 董顺福[1] 韩丽琴[1] 朱志国[1] 国巍[2] 陈默然[1] 钟越[1] 

机构地区：[1]吉林医药学院,吉林吉林132013 [2]吉林大学基础医学部,长春130021

出　　处：《微量元素与健康研究》2008年第1期1-2,共2页Studies of Trace Elements and Health

基　　金：吉林省(教育厅)高校科技与社科"十五"科研规划项目专项立项(吉教合字第192号)

摘　　要：目的:了解大鼠急性肺损伤(ALI)铬水平的变化及参脉对其的影响。方法:将ALI实验动物随机分为12组,其中6组为参脉治疗组,ALI后均立即给予参脉治疗,依照采集肺组织标本不同时间点分为:6 h、8 h、12 h1、6 h和24 h组(均12 h追加一次参脉)、36 h组(12和24 h各追加一次参脉);用生理盐水替换参脉为6组对照组。用原子分光光度计检测肺组织铬含量。结果:治疗组组间、对照组组间有明显差异(P<0.05);各时间点治疗组与对照组差异明显(P<0.05或P<0.01)。除治疗12 h组外,治疗组均高于对照组。结论:铬含量能在参脉干预下提高,对于改善全身状态和加速炎症损伤的修复有一定作用。Objective：Understand the change of the Chrome level, on the rats suffered ALI, and the infuluence of Shenmai effects on them. Method： Divide the rats into 12 sets, 6 sets among which are therapied by Shenmai（giveall of them Shenmai immediately after ALI）, while substitute the Shenmai by NS in the other 6 sets. In addition, to distinguis＋h the therapied sets according to the different time point of the sample（ the tissue of lung） as： 6 h set, 8 h set,12 h set,1 h set and 24 h set（ all annex Shenmai for just one time per 12 hs ） ,and 36 h set（ annex Shenmai for twice per 12 hs） ; the NS- substituted sets are distinguished in the same way. Then, use the atom spectrophotometer to detect the content of Chrome in the samples. Result：Among the therapied sets and comparison sets show the significant change （ P 〈 0.05 ） ; therapied sets and comparison sets in each time show the significant change （ P 〈 0.05 或 P 〈 0.01 ） ; except 12 h, therapied sets are higher than comparison sets. Conclusion：The level of Chrome step up transiently by Shenmai, it has some action to recover whole body and inflammation.

关 键 词：急性肺损伤 铬 参脉 

分 类 号：R563[医药卫生—呼吸系统] R446.1[医药卫生—内科学]