正交试验优选复方苦黄乳膏乳化工艺  

Optimization of Emulsifying Technology of Compound Kuhang Cream

作　　者：谢华[1] 贾云志[1] 

机构地区：[1]郑州大学第五附属医院,郑州市450052

出　　处：《中国药房》2008年第3期190-191,共2页China Pharmacy

摘　　要：目的:优选复方苦黄乳膏的乳化工艺。方法:采用正交试验法,以所制乳膏离心分层后油层的高度为考察指标,对影响乳膏稳定性的主要因素进行优选。结果:最佳工艺为油相硬酯酸∶单硬酯酸甘油酯∶羊毛脂∶液体石蜡∶白凡士林=4∶1∶2∶2∶1,乳化剂用量为4%,亲水疏水平衡值为13,乳化温度为80℃。结论:优选得到的工艺稳定可行,可为工业化生产提供理论依据。OBJECTIVE： To optimize the emulsifying technology of Compound kuhuang cream. METHODS： The factors influencing the stability of the cream were optimized by orthogonal experiment with the thickness of the oil layer obtained after centrifugalization and substratification of cream as index. RESULTS： The optimum condition was obtained when the ratio of oil-phase stearine ： glyceryl monostearate ： lanoline ： liguid paraffin ： white vaseline was 4 ： 1 ： 2 ： 2 ： 1, the proportion of emulsifier was 4%, the hydrophile- lipophile balance （HLB） was 1：3 and the emulsion temperature was 8012. CONCLUSION： The optimized emulsifying technology is stable and feasible and provides theoretic basis for the industrial production of Compound kuhuang cream.

关 键 词：复方苦黄乳膏 乳化工艺 正交试验 

分 类 号：R283.621[医药卫生—中药学] R284.2[医药卫生—中医学]