苁蓉片治疗地方性氟中毒的临床疗效观察  

Cistanche Salsa Tablets for Endemic Fluorosis:Observation of Clinical Efficacy

作　　者：黄长青 张兵 许宏伟 唐红艳 杨德民[2] 刘权[2] 王成海[3] 罗继 韩昌 赵魁 张小东[3] 

机构地区：[1]林省地方病第一防治研究所,白城市137000 [2]吉林白城市疾病预防控制中心,白城市137000 [3]吉林乾安县疾病预防控制中心,乾安县131400 [4]吉林洮南市疾病预防控制中心,洮南市137100

出　　处：《中国药房》2008年第3期217-219,共3页China Pharmacy

摘　　要：目的：观察苁蓉片治疗地方性氟中毒的临床疗效。方法：在地方性氟中毒中、重病区选择137例患者，其中37例作为治疗组，给予苁蓉片，口服，每次1．2g，每日2次；其余100例作为对照组，给予布洛芬缓释胶囊，口服，每次300mg，每日2次。疗程为4周。观察2种药物的总体疗效、起效时间、不良反应及患者对药物的耐受性。结果：治疗组总有效率为86．49％；起效时间在7～15d内；不良反应发生率为35．14％，与对照组比较均有显著性差异。2组患者对药物的耐受性均较好。结论：苁蓉片是治疗地方性氟中毒的有效药物，疗效优于布洛芬缓释胶囊。OBJECTIVE： To observe the clinical efficacy of Cistanche salsa tablets in treating endemic fluorosis. METHODS： A total of 137 cases were enrolled from endemic fluorosis disease - stricken area： 37 were assigned to receive Cistanche salsa tablets （1.2 g） po bid （trial group）, and another 100 to receive Fenbid （300 mg） po bid as control for a treatment course of 4 weeks. The outcome measures included the total efficacy, time to take effect, adverse drug reaction and patients＇ drug tolerance. RESULTS： In the trial group, the total effective rate was 86.49%, the time to take effect ranged from 7 to 15 days, and the ADR incidence rate was 35.14%, which was of significant difference as compared with control group.The patients in both groups had good drug tolerance. CONCLUSION： Cistanche salsa tablets are effective for endemic fluorosis and superior to Fenbid in efficacy.

关 键 词：地方性氟中毒 苁蓉片 布洛芬缓释胶囊 临床疗效 

分 类 号：R283.64[医药卫生—中药学] R979.3[医药卫生—中医学]