氟罗沙星对泌尿生殖道感染的疗效及其急性毒性试验  

Observation on Acute Toxicity and Effect of Fleroxacinum Against Genitourinary Infection

作　　者：吴友良[1] 乔着义[1] 章伟[1] 张浩[1] 高军[1] 

机构地区：[1]中国人民解放军第三二四医院,重庆400020

出　　处：《中国药业》2008年第3期7-8,共2页China Pharmaceuticals

摘　　要：目的考察氟罗沙星的临床疗效与急性毒性作用。方法应用氟罗沙星(治疗组)与氧氟沙星(对照组)治疗急性泌尿生殖道感染65例,同时选用小鼠静脉及腹腔注射两种途径进行急性毒性试验,按Bliss法程序统计处理。结果两组疗效比较有显著差异(P<0.01),治疗组优于对照组;小鼠静脉及腹腔注射半数致死量(LD50)分别为366.93mg/kg和614.44mg/kg。结论氟罗沙星治疗急性泌尿生殖道感染疗效确切,副作用小。Objective To investigate the therapeutic effect and acute toxicity of fleroxacinum. Methods 65 patients with acute genitourinary infection were treated with fleroxacinum （treatment group） and ofloxacinum （control group） respectively. The toxicity experiment was conducted with mouse intravenous and intraperitoneal injection. The data were statistically analyzed by BLISS. Results The therapeutical effects had significant difference between the two groups （P〈0. 01）. The treatment group was superior to the control group. Mouse LD50 was 366, 93 mg/kg and 614, 44 mg/kg for intravenous and intraperitoneal injection. Conclusion Fleroxacinum is effective with fewer side effect. The toxicity is the same as reported in relative literature. Fleroxacinum is the ideal antibacterial medicine against acute genitourinary infection.

关 键 词：氟罗沙星 疗效 急性毒性试验 

分 类 号：R978.69[医药卫生—药品] R969.4[医药卫生—药学]